Spermine NONOate
Based on 2 publication(s) in Google Scholar
Spermine NONOate is a complex of nitric oxide (NO) with spermine and acts as a NO donor. Spermine NONOate can be used for NO aqueous solutions preparing.
For research use only. We do not sell to patients.
- Purity: 98.07%
- CAS No.: 136587-13-8
- Formula: C10H26N6O2
- Molecular Weight:262.35
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Storage:
-80°C, protect from light, stored under nitrogen
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Spermine NONOate
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Biological Activity
Spermine NONOate has a half-life of 39 minutes and 230 minutes at 37°C and 22-25°C, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 136587-13-8
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Appearance Solid
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Molecular Weight 262.35
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Formula C10H26N6O2
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Color White to off-white
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SMILES
NCCCNCCCCN(CCCN)N(O)N=O
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light, stored under nitrogen
Publications (2)
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Journal Impact Factor
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Most Recent
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Antioxidants (Basel)
2025 Mar 4;14(3):311. PMID: 40227269 -
Front Pharmacol
Long-term nitric oxide exposure induces cough hypersensitivity via non-inflammatory activation of the HIF1α-TRPV1 pathway. [Abstract]2026 Jan 19:17:1679727. PMID: 41635485
Solvent & Solubility
H2O : ≥ 100 mg/mL (381.17 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (190.59 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. A Ramamurthi , et al. Measurement and modeling of nitric oxide release rates for nitric oxide donors. Chem Res Toxicol. 1997 Apr;10(4):408-13. [Content Brief]
[2]. K Homer, et al. In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries. Eur J Pharmacol. 1998 Aug 28;356(1):49-57. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.8117 mL | 19.0585 mL | 38.1170 mL | 95.2925 mL |
| 5 mM | 0.7623 mL | 3.8117 mL | 7.6234 mL | 19.0585 mL | |
| 10 mM | 0.3812 mL | 1.9059 mL | 3.8117 mL | 9.5293 mL | |
| 15 mM | 0.2541 mL | 1.2706 mL | 2.5411 mL | 6.3528 mL | |
| 20 mM | 0.1906 mL | 0.9529 mL | 1.9059 mL | 4.7646 mL | |
| 25 mM | 0.1525 mL | 0.7623 mL | 1.5247 mL | 3.8117 mL | |
| 30 mM | 0.1271 mL | 0.6353 mL | 1.2706 mL | 3.1764 mL | |
| 40 mM | 0.0953 mL | 0.4765 mL | 0.9529 mL | 2.3823 mL | |
| 50 mM | 0.0762 mL | 0.3812 mL | 0.7623 mL | 1.9059 mL | |
| 60 mM | 0.0635 mL | 0.3176 mL | 0.6353 mL | 1.5882 mL | |
| 80 mM | 0.0476 mL | 0.2382 mL | 0.4765 mL | 1.1912 mL | |
| 100 mM | 0.0381 mL | 0.1906 mL | 0.3812 mL | 0.9529 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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