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Cat. No.: HY-N6622

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Tazettine

Tazettine is an alkaloid with low cytotoxicity to mammalian cell lines (CC50 >100 μg/mL).

For research use only. We do not sell to patients.

CAS No.: 507-79-9
Formula: C₁₈H₂₁NO₅
Molecular Weight:331.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Tazettine Chemical Structure

CAS No.: 507-79-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Tazettine is an alkaloid with low cytotoxicity to mammalian cell lines (CC50 >100 μg/mL)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	ED₅₀	11.1 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
A549	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
A549	IC₅₀	>10 μM Compound: 4	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 23190013]
B16-F10	IC₅₀	>10 μM Compound: 10	Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against mouse B16F10 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
BC1 cell line	ED₅₀	>20 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human BC1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human BC1 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
Col2	ED₅₀	5 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human Col2 cells after 3 days by sulforhodamine B assay Cytotoxicity against human Col2 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
HepG2	IC₅₀	>10 μM Compound: 4	Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 23190013]
HL-60	IC₅₀	>10 μM Compound: 4	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 23190013]
Hs 683	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human Hs683 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
HT	ED₅₀	11.8 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human HT cells after 3 days by sulforhodamine B assay Cytotoxicity against human HT cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
HT-29	IC₅₀	>10 μM Compound: 4	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 23190013]
K562	IC₅₀	>10 μM Compound: 4	Cytotoxicity against human K562 cells after 48 hrs by MTT assay Cytotoxicity against human K562 cells after 48 hrs by MTT assay	[PMID: 23190013]
KB	ED₅₀	7.3 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
KB-V1	ED₅₀	>20 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human KBV1 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
LNCaP	ED₅₀	5.9 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
Lu1	ED₅₀	11.1 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human Lu1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human Lu1 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
P388	ED₅₀	1 μg/mL Compound: (+)-Tazettine	Cytotoxicity against mouse P388 cells after 3 days by sulforhodamine B assay Cytotoxicity against mouse P388 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
SK-MEL	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human SK-MEL cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
SK-MEL-2	ED₅₀	12.9 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]
U-373MG ATCC	IC₅₀	>10 μM Compound: 10	Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay Cytotoxicity against human U373 cells after 72 hrs by MTT colorimetric assay	[PMID: 20550100]
ZR-75-1	ED₅₀	6.9 μg/mL Compound: (+)-Tazettine	Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay	[PMID: 8229020]

Chemical Information

CAS No. 507-79-9
Molecular Weight 331.36
Formula C₁₈H₂₁NO₅
SMILES

O[C@@]12[C@]3([C@@](C[C@@H](C=C3)OC)([H])N(C2)C)C4=CC(OCO5)=C5C=C4CO1
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Brine ND, et al. A dinitrogenous alkaloid from Cyrtanthus obliquus. Phytochemistry. 2002 Oct;61(4):443-7. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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