PSD4 - pleckstrin and Sec7 domain containing 4 Gene

Also Known as TIC; EFA6B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23550

About PSD4

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,173,971-113,209,391 (from NCBI)

This gene has 12 transcripts (splice variants), 129 orthologues and 15 paralogues. Ubiquitous expression in lymph node (RPKM 21.5), spleen (RPKM 20.1) and 22 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity and phospholipid binding activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of catalytic activity. Located in ruffle membrane. [provided by Alliance of Genome Resources, Apr 2022]

PSD4 Products (1)

mRNA Protein Name
NM_012455.3 NP_036587.2 PH and SEC7 domain-containing protein 4

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25910212 GOA
Cellular Component GO Annotation Evidence References Source
NOT located in cleavage furrow IDA
IDA: Inferred from direct assay
23603394 GOA
located in ruffle membrane IDA
IDA: Inferred from direct assay
23603394 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSD4 Protein Structure

Sec7

Sec7: Sec7 domain (584 - 737)

PH_9

PH_9: Pleckstrin homology domain (778 - 892)

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  • 1056 a.a.
Protein Preferred Names Protein Names

PH and SEC7 domain-containing protein 4

  • ADP-ribosylation factor guanine nucleotide-exchange factor 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11275 PSD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PSD4 VGNC VGNC:33433
Rattus norvegicus PSD4 RGD RGD:1310289
Felis catus PSD4 VGNC VGNC:64410
Mus musculus PSD4 MGD MGI:2674093
Canis familiaris PSD4 VGNC VGNC:45084
Macaca mulatta PSD4 VGNC VGNC:76287
Others PSD4 NCBI