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SCUBE2 - signal peptide, CUB domain and EGF like domain containing 2 Gene

Also Known as CEGB1; CEGF1; CEGP1; scube/You

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57758

About SCUBE2

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,019,476-9,091,599 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues and 2 paralogues. Broad expression in prostate (RPKM 8.1), urinary bladder (RPKM 7.3) and 20 other tissues.

Summary

Predicted to enable calcium ion binding activity; Hedgehog family protein binding activity; and lipid binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including positive regulation of chondrocyte proliferation; positive regulation of osteoblast differentiation; and positive regulation of smoothened signaling pathway. Predicted to be located in extracellular region. Predicted to be active in cell surface and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SCUBE2 Products (4)

mRNA	Protein	Name
NM_001170690.3	NP_001164161.1	signal peptide, CUB and EGF-like domain-containing protein 2 isoform 2 precursor
NM_001330199.3	NP_001317128.1	signal peptide, CUB and EGF-like domain-containing protein 2 isoform 3 precursor
NM_001367977.2	NP_001354906.1	signal peptide, CUB and EGF-like domain-containing protein 2 isoform 4 precursor
NM_020974.4	NP_066025.2	signal peptide, CUB and EGF-like domain-containing protein 2 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12270931	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCUBE2 Protein Structure

EGF_CA

cEGF

FXa_inhibition

EGF_CA

FXa_inhibition

Ephrin_rec_like

CUB

0
200
400
600
800
971 a.a.

Protein Preferred Names	Protein Names
signal peptide, CUB and EGF-like domain-containing protein 2

Related Diseases

Diseases	Alias
Arteriovenous Malformations Of The Brain	Cerebral Arteriovenous Malformation Intracranial Arteriovenous Malformation Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To Intracranial Arteriovenous Malformations Bavm Cerebral Arteriovenous Malformations Intracranial Hemorrhage In Brain Cerebrovascular Malformations Arteriovenous Malformation Of The Brain, Somatic Intracranial Avm Arteriovenous Malformations Cerebral
Central Nervous System Tuberculosis	Intracranial Tuberculoma Tuberculoma Of Brain Tuberculosis Of Meninges And Central Nervous System Tuberculous Abscess Of Brain Tuberculoma, Intracranial Tuberculosis, Central Nervous System

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12572	SCUBE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SCUBE2	RGD	RGD:1563998
Felis catus	SCUBE2	VGNC	VGNC:64938
Canis familiaris	SCUBE2	VGNC	VGNC:45936
Bos taurus	SCUBE2	VGNC	VGNC:34372
Macaca mulatta	SCUBE2	VGNC	VGNC:77138
Mus musculus	SCUBE2	MGD	MGI:1928765
Others	SCUBE2	NCBI