CD9 - CD9 molecule Gene

Also Known as MIC3; MRP-1; BTCC-1; DRAP-27; TSPAN29; TSPAN-29

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 928

About CD9

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,199,946-6,238,266 (from NCBI)

This gene has 25 transcripts (splice variants), 353 orthologues and 32 paralogues. Broad expression in esophagus (RPKM 210.8), prostate (RPKM 168.1) and 21 other tissues.

Summary

This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with Other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of Cancer cell motility and metastasis. [provided by RefSeq, Jan 2011]

CD9 Products (14)

mRNA Protein Name
NM_001330312.2 NP_001317241.1 CD9 antigen isoform 2
NM_001413241.1 NP_001400170.1 CD9 antigen isoform 3
NM_001413242.1 NP_001400171.1 CD9 antigen isoform 4
NM_001413243.1 NP_001400172.1 CD9 antigen isoform 1
NM_001413244.1 NP_001400173.1 CD9 antigen isoform 5
NM_001413245.1 NP_001400174.1 CD9 antigen isoform 6
NM_001413246.1 NP_001400175.1 CD9 antigen isoform 7
NM_001413247.1 NP_001400176.1 CD9 antigen isoform 8
NM_001413248.1 NP_001400177.1 CD9 antigen isoform 9
NM_001413249.1 NP_001400178.1 CD9 antigen isoform 2
NM_001413250.1 NP_001400179.1 CD9 antigen isoform 2
NM_001413251.1 NP_001400180.1 CD9 antigen isoform 2
NM_001413252.1 NP_001400181.1 CD9 antigen isoform 2
NM_001769.4 NP_001760.1 CD9 antigen isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IDA
IDA: Inferred from direct assay
12796480 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11278880 GOA
Biological Process GO Annotation Evidence References Source
involved in cell adhesion IDA
IDA: Inferred from direct assay
7511626 GOA
involved in fusion of sperm to egg plasma membrane involved in single fertilization IDA
IDA: Inferred from direct assay
14575715 GOA
involved in glial cell migration IMP
IMP: Inferred from mutant phenotype
26224160 GOA
involved in negative regulation of platelet aggregation IDA
IDA: Inferred from direct assay
18541721 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular exosome IDA
IDA: Inferred from direct assay
15326289 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
15344881 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD9 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (9 - 221)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

CD9 antigen

  • 5H9 antigen

CD9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CD9 P21926 ODF4 Homo sapiens Q2M2E3
Y2H Prey Pooling
32296183
Intra
CD9 P21926 ODF4 Homo sapiens Q2M2E3
Validated Y2H
32296183
Intra
CD9 P21926 ODF4 Homo sapiens Q2M2E3
Y2H Array
32296183
Intra
CD9 P21926 ADAM10 Homo sapiens O14672
Confocal
26686862
Intra
CD9 P21926 ADAM10 Homo sapiens O14672
Anti Tag CoIP
26686862
Intra
CD9 P21926 ADAM10 Homo sapiens O14672
Anti Bait CoIP
23091066
Intra
CD9 P21926 ADAM10 Homo sapiens O14672
Anti Bait CoIP
23289620
Intra
CD9 P21926 ADAM10 Homo sapiens O14672
Anti Bait CoIP
26686862
Intra
CD9 P21926 MME Homo sapiens P08473
Anti Bait CoIP
23289620
Intra
CD9 P21926 PTGFRN Homo sapiens Q9P2B2
Anti Bait CoIP
23091066
Intra
CD9 P21926 PTGFRN Homo sapiens Q9P2B2
Pull Down
30833792
Intra
CD9 P21926 PTGFRN Homo sapiens Q9P2B2
Anti Bait CoIP
26686862
Intra
CD9 P21926 PTGFRN Homo sapiens Q9P2B2
Anti Tag CoIP
26686862
Intra
CD9 P21926 PTGFRN Homo sapiens Q9P2B2
Anti Bait CoIP
23289620
Intra
CD9 P21926 PTGFRN Homo sapiens Q9P2B2
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CD9 Proteins

Cat. No. Product Name Accession Purity
HY-P72701 CD9 Protein, Human (HEK293, His) P21926 (S112-I195) ≥ 95%, as determined by reducing SDS-PAGE.

CD9 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80068 CD9 Antibody (YA524) WB, ICC/IF, IHC-P, IP Human, Mouse
HY-P80610 CD9 Antibody WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P80610A CD9 Antibody (YA7185) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P80610AA CD9 Antibody (YA7185)(PBS only) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat
HY-P86394 CD9 Antibody (YA6086) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Diphtheria

  • Corynebacterium Infections

  • Corynebacterium Infection

  • Diphtherial Infection

  • Infection Due To Corynebacterium Diphtheriae
Human Immunodeficiency Virus Infectious Disease

  • Hiv Infections
Cytomegalovirus Retinitis

  • Cmv Retinitis
Malignant Hypertensive Renal Disease
Benign Hypertensive Renal Disease

  • Hypertensive Renal Disease, Benign

  • Hypertensive Renal Disease, Benign, Without Mention Of Renal Failure
Human Immunodeficiency Virus Type 1

  • Aids

  • Hiv/Aids

  • Aids, Delayed/Rapid Progression To

  • Hiv-1, Susceptibility To

  • Hiv-1 Viremia, Susceptibility To

  • Human Immunodeficiency Virus Type 1, Susceptibility To

  • Hiv-1

  • Aids, Slow Progression To

  • Rapid Progression To Aids From Hiv1 Infection

  • Hiv1 Infection, Resistance To

  • Hiv1 Infection

  • Hiv-1 Viremia

  • Aids, Resistance To

  • Aids, Rapid Progression To

  • Hiv/Aids, Susceptibility To

  • Hiv-1, Resistance To

  • Hiv1, Resistance To

  • Hiv1

  • Hiv-1 Disease, Delayed Progression Of

  • Hiv-1 Disease, Rapid Progression Of

  • Hiv Infection, Resistance To

  • Hiv Type 1, Susceptibility To

  • Hiv Type 1

  • Hiv-1 Infection

  • Human Immunodeficiency Virus I Infection

  • Acquired Immunodeficiency Syndrome

  • Hiv-Infection/Aids
Bernard-Soulier Syndrome

  • Giant Platelet Syndrome

  • BSS

  • Von Willebrand Factor Receptor Deficiency

  • Bdplt1

  • Platelet Glycoprotein Ib Deficiency

  • Bernard-Soulier Syndrome, Type A1

  • Bernard-Soulier Syndrome, Type B

  • Bernard Soulier Syndrome

  • Deficiency Of Platelet Glycoprotein 1b

  • Hemorrhagiparous Thrombocytic Dystrophy

  • Bernard-Soulier Syndrome Type C

  • Bleeding Disorder, Platelet-Type, 1

  • Glycoprotein Ib, Platelet, Deficiency Of

  • Giant Platelet Disorder, Isolated

  • Giant Platelet Disease

  • Macrothrombocytopenia, Familial Bernard-Soulier Type

  • Bernard-Soulier Syndrome, Type C

  • Bernard - Soulier Thrombopathy

  • Hemorrhagic Dystrophic Thrombocytopenia

  • Thrombopathy, Bernard-Soulier

  • Platelet Glycoprotein 1b, Deficiency Of

  • Hemorrhagioparous Thrombocytic Dystrophy

  • Bernard-Soulier Syndrome Type A1

  • Bernard-Soulier Syndrome Type B

  • Bleeding Disorder Platelet-Type 1

  • Gpd

  • Macrothrombocytopenia, Familial, Bernard-Soulier Type
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Acquired Immunodeficiency Syndrome

  • Acquired Immune Deficiency Syndrome

  • AIDS

  • Acquired Immune Deficiency

  • Acquired Immunodeficiency

  • Acquired Immunodeficiency Due To Protein Loss
Inflammatory Bowel Disease 4

  • IBD4
Glanzmann Thrombasthenia 1

  • Glanzmann Thrombasthenia

  • Thrombasthenia Of Glanzmann And Naegeli

  • Glanzmann'S Thrombasthenia

  • Bdplt2

  • Platelet Glycoprotein Iib-Iiia Deficiency

  • Deficiency Of Platelet Fibrinogen Receptor

  • GT1

  • Gt

  • Platelet Fibrinogen Receptor Deficiency

  • Glycoprotein Complex Iib-Iiia Deficiency

  • Deficiency Of Glycoprotein Complex Iib-Iiia

  • Glycoprotein Iib/Iiia Defect

  • Glanzmann Thrombasthenia, Type A

  • Thrombasthenia

  • Bleeding Disorder, Platelet-Type, 2

  • Gp Iib-Iiia Complex Deficiency

  • Deficiency Of Gp Iib-Iiia Complex

  • Platelet-Type Bleeding Disorder 2

  • Thrombocytasthenia

  • Deficiency Of Gp 2b 3a Complex

  • Diacyclothrombopathia 2b 3a

  • Glanzmann Thrombasthenia Type A

  • Platelet Fibrinogen Receptor, Deficiency Of

  • Platelet Glycoprotein 2b 3a Deficiency

  • Glanzmann Disease

  • Glanzmann-Naegeli Disorder

  • Hereditary Hemorrhagic Thrombasthenia

  • Hereditary Thrombasthenia

  • Bleeding Disorder Platelet-Type 2
Viral Infectious Disease

  • Viral Disease

  • Arbovirus Infections

  • Virus Infection

  • Virus Diseases

  • Viral Infection

  • Viral Infections

  • Virus Infections
Plasmacytoma

  • Solitary Plasmacytoma

  • Solitary Myeloma

  • Myeloma - Solitary

  • Myeloma, Solitary

  • Plasmacytoma - Category

  • Solitary Osseous Plasmacytoma

  • Solitary Plasmacytoma Without Mention Of Remission

  • Localised Malignant Plasma Cell Tumour Nos

  • Plasmacytoma Nos
Kaposi Sarcoma

  • Kaposi'S Sarcoma

  • Kaposi Sarcoma, Susceptibility To

  • Kaposi'S Sarcoma Of Lung

  • Kaposi'S Sarcoma Of Palate

  • Kaposi'S Sarcoma Of Soft Tissue

  • Kaposi'S Sarcoma-Associated Herpesvirus

  • Multiple Idiopathic Pigmented Hemangiosarcoma

  • Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To

  • African Lymphadenopathic Kaposi'S Sarcoma

  • Anal Kaposi'S Sarcoma

  • Cardiac Kaposi'S Sarcoma

  • Central Nervous System Kaposi'S Sarcoma

  • Conjunctival Kaposi'S Sarcoma

  • Corneal Kaposi'S Sarcoma

  • Cutaneous Kaposi'S Sarcoma

  • Esophageal Kaposi'S Sarcoma

  • Gallbladder Kaposi'S Sarcoma

  • Gastric Kaposi'S Sarcoma

  • Intestinal Kaposi'S Sarcoma

  • Kaposi'S Sarcoma Of Anus

  • Kaposi'S Sarcoma Of Central Nervous System

  • Kaposi'S Sarcoma Of Conjunctiva

  • Kaposi'S Sarcoma Of Cornea

  • Kaposi'S Sarcoma Of Esophagus

  • Kaposi'S Sarcoma Of Gastrointestinal Sites

  • Kaposi'S Sarcoma Of Heart

  • Kaposi'S Sarcoma Of Lymph Nodes

  • Kaposi'S Sarcoma Of Penis

  • Kaposi'S Sarcoma Of Skin

  • Kaposi'S Sarcoma Of Soft Tissues

  • Kaposi'S Sarcoma Of The Cns

  • Kaposi'S Sarcoma Of The Gallbladder

  • Kaposi'S Sarcoma Of The Prostate

  • Kaposi'S Sarcoma, Lung

  • Kaposi'S Sarcoma, Skin

  • Lymph Node Kaposi'S Sarcoma

  • Lymphadenopathic Kaposi'S Sarcoma

  • Palate Kaposi'S Sarcoma

  • Penis Kaposi'S Sarcoma

  • Prostate Kaposi'S Sarcoma

  • Pulmonary Kaposi'S Sarcoma

  • Soft Tissue Kaposi'S Sarcoma

  • Hhv8

  • Human Herpesvirus 8

  • Kshv

  • Kaposi Sarcoma Herpesvirus

  • Mediterranean Kaposi Sarcoma

  • Non Aids Related Kaposi Sarcoma

  • Sarcoma, Kaposi

  • Sarcoma, Kaposi, Susceptibility To

  • Non-Aids-Related Kaposi Sarcoma

  • Angiolymphoid Hyperplasia

  • Angiofollicular Ganglionic Hyperplasia

  • Multi-Centric Castleman'S Disease
Myelofibrosis

  • Primary Myelofibrosis

  • Agnogenic Myeloid Metaplasia

  • Idiopathic Myelofibrosis

  • Myeloid Metaplasia

  • Myelofibrosis With Myeloid Metaplasia

  • Osteomyelofibrosis

  • Megakaryocytic Myelosclerosis

  • Myelosclerosis

  • Chronic Idiopathic Myelofibrosis

  • Myelofibrosis, Idiopathic

  • Myelofibrosis With Myeloid Metaplasia, Somatic

  • Myelofibrosis, Somatic

  • Aleukemic Myelosis

  • Bone Marrow Fibrosis

  • MYELOF

  • MMM

  • Agnogenic Myeloid Metaplasia With Myelofibrosis

  • Ammm

  • Myelosclerosis With Myeloid Metaplasia

  • Myelofibrosis Nos
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Myeloma, Multiple

  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02277 CD9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16773 Cd9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23213 Cd9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990361 Anti-CDCP1/CD318 Antibody (38 E11) ≥99.0% Unkown
HY-P990360 Anti-CD9 Antibody 99.52% Unkown
HY-P991896 AT1412 Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CD9 VGNC VGNC:27053
Rattus norvegicus CD9 RGD RGD:2318
Mus musculus CD9 MGD MGI:88348
Canis familiaris CD9 VGNC VGNC:38981
Macaca mulatta CD9 VGNC VGNC:70787
Felis catus CD9 VGNC VGNC:83520
Others CD9 NCBI