ADAM10 - ADAM metallopeptidase domain 10 Gene

Also Known as RAK; kuz; AD10; AD18; MADM; CD156c; CDw156; HsT18717

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 102

About ADAM10

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:58,588,809-58,749,707 (from NCBI)

This gene has 17 transcripts (splice variants), 371 orthologues, 20 paralogues and is associated with 3 phenotypes. Ubiquitous expression in urinary bladder (RPKM 30.9), thyroid (RPKM 26.8) and 25 other tissues.

Summary

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]

ADAM10 Products (2)

mRNA	Protein	Name
NM_001110.4	NP_001101.1	disintegrin and metalloproteinase domain-containing protein 10 isoform 1 preproprotein
NM_001320570.2	NP_001307499.1	disintegrin and metalloproteinase domain-containing protein 10 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	24990881	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	18676862	GOA
enables metalloendopeptidase activity	IMP IMP: Inferred from mutant phenotype	19114711	GOA
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	28164773	GOA
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	12475894	GOA
enables metallopeptidase activity	IMP IMP: Inferred from mutant phenotype	12535668	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10527948	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	25349418	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	28164773	GOA
involved in constitutive protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	12714508	GOA
acts upstream of or within membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	18355449	GOA
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	12714508	GOA
involved in membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	17965014	GOA
involved in monocyte activation	IMP IMP: Inferred from mutant phenotype	11831872	GOA
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	12714508	GOA
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24530397	GOA
involved in pore complex assembly	IMP IMP: Inferred from mutant phenotype	30463011	GOA
involved in positive regulation of T cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18373975	GOA
involved in response to tumor necrosis factor	IDA IDA: Inferred from direct assay	11831872	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12475894	GOA
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	12475894	GOA
located in cell surface	IDA IDA: Inferred from direct assay	12475894	GOA
located in perinuclear endoplasmic reticulum	IDA IDA: Inferred from direct assay	23091066	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	20624979	GOA
part of pore complex	IMP IMP: Inferred from mutant phenotype	30463011	GOA
located in synaptic membrane	IDA IDA: Inferred from direct assay	23676497	GOA
located in tetraspanin-enriched microdomain	IDA IDA: Inferred from direct assay	23035126	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM10 Protein Structure

Pep_M12B_propep

Reprolysin_2

Disintegrin

0
200
400
600
748 a.a.

Protein Preferred Names	Protein Names
disintegrin and metalloproteinase domain-containing protein 10	a disintegrin and metalloprotease domain 10 kuzbanian protein homolog mammalian disintegrin-metalloprotease

ADAM10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ADAM10	O14672	TSPAN33	Homo sapiens	Q86UF1	Anti Tag CoIP	23091066
Intra	ADAM10	O14672	TSPAN33	Homo sapiens	Q86UF1	IF	23091066
Intra	ADAM10	O14672	LCK	Homo sapiens	P06239	Pull Down	25036101
Intra	ADAM10	O14672	LCK	Homo sapiens	P06239	Phage Display	25036101
Intra	ADAM10	O14672	LCK	Homo sapiens	P06239	Anti Bait CoIP	25036101
Intra	ADAM10	O14672	TSPAN5	Homo sapiens	P62079	Anti Bait CoIP	23091066
Intra	ADAM10	O14672	TSPAN5	Homo sapiens	P62079	Anti Tag CoIP	23091066
Intra	ADAM10	O14672	TSPAN5	Homo sapiens	P62079	Anti Bait CoIP	26686862
Intra	ADAM10	O14672	TSPAN5	Homo sapiens	P62079	IF	23091066
Intra	ADAM10	O14672	BACE1	Homo sapiens	P56817	BiFC	30538620
Intra	ADAM10	O14672	BACE1	Homo sapiens	P56817	FRET	30538620
Intra	ADAM10	O14672	GRAP	Homo sapiens	Q13588	Pull Down	25036101
Intra	ADAM10	O14672	SNX18	Homo sapiens	Q96RF0	Pull Down	25036101
Intra	ADAM10	O14672	SNX18	Homo sapiens	Q96RF0	Phage Display	25036101
Intra	ADAM10	O14672	HCK	Homo sapiens	P08631	Pull Down	25036101
Intra	ADAM10	O14672	ABL1	Homo sapiens	P00519	Pull Down	25036101
Intra	ADAM10	O14672	ABL1	Homo sapiens	P00519	Phage Display	25036101
Intra	ADAM10	O14672	GRB2	Homo sapiens	P62993	Phage Display	25036101
Intra	ADAM10	O14672	GRB2	Homo sapiens	P62993	Anti Bait CoIP	25036101
Intra	ADAM10	O14672	GRB2	Homo sapiens	P62993	Pull Down	25036101
Intra	ADAM10	O14672	CD9	Homo sapiens	P21926	Anti Bait CoIP	26686862
Intra	ADAM10	O14672	CD9	Homo sapiens	P21926	Anti Bait CoIP	23091066
Intra	ADAM10	O14672	FYN	Homo sapiens	P06241	Pull Down	25036101
Intra	ADAM10	O14672	YES1	Homo sapiens	P07947	Pull Down	25036101
Intra	ADAM10	O14672	SRC	Homo sapiens	P12931	Phage Display	25036101
Intra	ADAM10	O14672	SRC	Homo sapiens	P12931	Pull Down	25036101
Intra	ADAM10	O14672	TSPAN14	Homo sapiens	Q8NG11	Anti Tag CoIP	23091066
Intra	ADAM10	O14672	TSPAN14	Homo sapiens	Q8NG11	Anti Bait CoIP	26686862
Intra	ADAM10	O14672	TSPAN14	Homo sapiens	Q8NG11	IF	23091066
Intra	ADAM10	O14672	TSPAN14	Homo sapiens	Q8NG11	Anti Bait CoIP	23091066
Intra	ADAM10	O14672	SH3GL1	Homo sapiens	Q99961	Phage Display	25036101
Intra	ADAM10	O14672	SH3GL1	Homo sapiens	Q99961	Pull Down	25036101
Intra	ADAM10	O14672	CD81	Homo sapiens	P60033	Anti Bait CoIP	26686862
Intra	ADAM10	O14672	CD81	Homo sapiens	P60033	Anti Bait CoIP	23091066
Intra	ADAM10	O14672	PACSIN1	Homo sapiens	Q9BY11	Pull Down	25036101
Intra	ADAM10	O14672	TSPAN15	Homo sapiens	O95858	Anti Bait CoIP	23091066
Intra	ADAM10	O14672	TSPAN15	Homo sapiens	O95858	Anti Bait CoIP	26686862
Intra	ADAM10	O14672	TSPAN15	Homo sapiens	O95858	Anti Tag CoIP	23091066
Intra	ADAM10	O14672	TSPAN15	Homo sapiens	O95858	IF	23091066
Intra	ADAM10	O14672	GRAP2	Homo sapiens	O75791	Pull Down	25036101
Intra	ADAM10	O14672	GRAP2	Homo sapiens	O75791	Phage Display	25036101
Intra	ADAM10	O14672	PACSIN2	Homo sapiens	Q9UNF0	Pull Down	25036101
Intra	ADAM10	O14672	APP	Homo sapiens	P05067	Y2H Array	32814053
Intra	ADAM10	O14672	APP	Homo sapiens	P05067	FRET	30538620
Intra	ADAM10	O14672	APP	Homo sapiens	P05067	Y2H Pooling	32814053
Intra	ADAM10	O14672	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	ADAM10	O14672	PACSIN3	Homo sapiens	Q9UKS6	Pull Down	25036101
Intra	ADAM10	O14672	PACSIN3	Homo sapiens	Q9UKS6	Phage Display	25036101

Cross: Cross-species interaction Intra: Intraspecies interaction

ADAM10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83547	ADAM10 Antibody (YA3292)	WB, IP	Human, Mouse, Rat
HY-P83804	ADAM10 Antibody (YA3501)	IHC-P, FC, ELISA	Human
HY-P83804A	ADAM10 Antibody (YA3501)(PBS only)	IHC-P, FC, ELISA	Human
HY-P86137	ADAM10 Antibody (YA5829)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Leech Infestation	Hirudiniasis Leeches
Scrapie
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Alzheimer Disease 18	AD18 Alzheimer'S Disease 18 Alzheimer Disease 18, Late-Onset Alzheimer Disease 18, Susceptibility To Alzheimer'S Disease 18, Late Onset Alzheimer Disease 18 Late-Onset Alzheimer Disease, Susceptibility To, Type 18
Dowling-Degos Disease 1	Reticular Pigment Anomaly Of Flexures DDD1 Ddd Dowling-Degos Disease Hyperpigmentation
Reticulate Acropigmentation Of Kitamura	RAK Acropigmentatio Reticularis Reticulate Pigmentation Of Kitamura Rpk Kitamura Reticulate Acropigmentation Rapk
Purulent Acute Otitis Media	Acute Suppurative Otitis Media Acute Or Subacute Suppurative Otitis Media Acute Or Subacute Purulent Otitis Media
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Purpura Fulminans	Purpura Gangrenosa
Cerebral Amyloid Angiopathy, Itm2b-Related, 1	Dementia, Familial British Fbd Presenile Dementia With Spastic Ataxia Familial British Dementia Abri Amyloidosis Cerebral Amyloid Angiopathy, British Type Itm2b-Related Cerebral Amyloid Angiopathy 1 Familial Dementia, British Type Cerebral Amyloid Angiopathy, Itm2b-Related 1 CAA-ITM2B1 Cerebral Amyloid Angiopathy British Type Dementia, Familial, British
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10293	Aderbasib	Inhibitor	99.44%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115670	GW280264X	Inhibitor	99.30%	Unkown
HY-16657	TAPI-1	Inhibitor	99.36%	Unkown
HY-110397	KP-457	Inhibitor	98.88%	Unkown
HY-120852	JG26	Inhibitor	98.14%	Unkown
HY-P3722A	Mca-PLAQAV-Dpa-RSSSR-NH2 TFA		99.54%	Unkown
HY-108675	PPNDS tetrasodium	Inhibitor	96.39%	Unkown
HY-P11540	CCKBR agonist-1	Agonist	98.48%	Unkown
HY-P3722	Mca-PLAQAV-Dpa-RSSSR-NH2	Substrate	99.33%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADAM10	MGD	MGI:109548
Canis familiaris	ADAM10	VGNC	VGNC:59103
Felis catus	ADAM10	VGNC	VGNC:59573
Bos taurus	ADAM10	VGNC	VGNC:25604
Rattus norvegicus	ADAM10	RGD	RGD:2032
Macaca mulatta	ADAM10	VGNC	VGNC:69465
Others	ADAM10	NCBI