PPNDS tetrasodium

Name: PPNDS tetrasodium
Brand: MedChemExpress
SKU: HY-108675
Rating: 4.5 (1 reviews)

Cat. No.: HY-108675 Purity: ≥89.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC₅₀: 80 nM, K_i: 8 nM), and also inhibits ADAM10 (IC₅₀: 1.2 μM). PPNDS tetrasodium is also a P2X1 receptor antagonist. PPNDS is an agonist for the ATP receptor of Paramecium. PPNDS tetrasodium potently inhibits polymerases from viruses. PPNDS tetrasodium can be used in the research of infection and cancers.

For research use only. We do not sell to patients.

PPNDS tetrasodium Chemical Structure

CAS No. : 1021868-77-8

Size	Price	Stock	Quantity
1 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 330	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

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View All Isoforms

MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

ADAM10

1.2 μM (IC₅₀)

p2x1 Receptor

In Vitro

PPNDS tetrasodium inhibits meprin β (IC₅₀: 80 nM) and meprin α (67 μM)^[1].
PPNDS tetrasodium (0-10 μM, 15 min) inhibits mNV-RdRp (murine Norovirus RNA-dependent RNA-polymerase) with an IC₅₀ value of 0.88 μM^[2].
PPNDS tetrasodium (0.025-10 µM) potently inhibits polymerases from six viruses spanning the three Caliciviridae genera tested (IC₅₀ range: 0.1-2.3 μM)^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

694.36

Formula

C₁₈H₁₁N₄Na₄O₁₄PS₂

CAS No.

1021868-77-8

Appearance

Solid

Color

Brown to reddish brown

SMILES

O=CC1=C(C(C)=NC(/N=N/C2=CC(S(=O)(O[Na])=O)=C(C=C([N+]([O-])=O)C=C3S(=O)(O[Na])=O)C3=C2)=C1COP(O[Na])(O[Na])=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 37.5 mg/mL (54.01 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.4402 mL	7.2009 mL	14.4018 mL
5 mM	0.2880 mL	1.4402 mL	2.8804 mL
10 mM	0.1440 mL	0.7201 mL	1.4402 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 96.39%

Select Batch:

Data Sheet (280 KB) SDS (251 KB)

COA (257 KB) RP-HPLC (276 KB) MS (72 KB)

Handling Instructions (2659 KB)

References

[1]. Franck Madoux, et al. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β. Biopolymers. 2014 Sep;102(5):396-406. [Content Brief]

[2]. Romina Croci, et al. PPNDS inhibits murine Norovirus RNA-dependent RNA-polymerase mimicking two RNA stacking bases. FEBS Lett. 2014 May 2;588(9):1720-5. [Content Brief]

[3]. Christopher R Wood, et al. PPNDS is an agonist, not an antagonist, for the ATP receptor of Paramecium. J Exp Biol. 2003 Feb;206(Pt 3):627-36. [Content Brief]

[4]. Natalie E Netzler, et al. Broad-spectrum non-nucleoside inhibitors for caliciviruses. Antiviral Res. 2017 Oct;146:65-75. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	1.4402 mL	7.2009 mL	14.4018 mL	36.0044 mL
	5 mM	0.2880 mL	1.4402 mL	2.8804 mL	7.2009 mL
	10 mM	0.1440 mL	0.7201 mL	1.4402 mL	3.6004 mL
	15 mM	0.0960 mL	0.4801 mL	0.9601 mL	2.4003 mL
	20 mM	0.0720 mL	0.3600 mL	0.7201 mL	1.8002 mL
	25 mM	0.0576 mL	0.2880 mL	0.5761 mL	1.4402 mL
	30 mM	0.0480 mL	0.2400 mL	0.4801 mL	1.2001 mL
	40 mM	0.0360 mL	0.1800 mL	0.3600 mL	0.9001 mL
	50 mM	0.0288 mL	0.1440 mL	0.2880 mL	0.7201 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.