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Cat. No.: HY-153713

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MYC-RIBOTAC

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

MYC-RIBOTAC is a nucleic acid-targeting degrader (ribonuclease-targeting chimera, RIBOTAC) that targets the MYC internal ribosome entry site (IRES). MYC-RIBOTAC contains a MYC mRNA binding component and a small molecule that recruits and locally activates RNAse L1. MYC-RIBOTAC reduces MYC mRNA and protein expression levels, induces cell apoptosis, and can be used for antitumor research. MYC-RIBOTAC consists of pre-miR-155 binder Anticancer agent 167 (HY-156839), RNA binder NCI-B16 (HY-156215), and Linker Amino-PEG4-alcohol (HY-W008005).

For research use only. We do not sell to patients.

Purity: 98.17%
Formula: C₅₅H₅₈N₁₀O₁₁S
Molecular Weight:1067.17

Storage:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

MYC-RIBOTAC Chemical Structure

Size

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

MYC-RIBOTAC is a nucleic acid-targeting degrader (ribonuclease-targeting chimera, RIBOTAC) that targets the MYC internal ribosome entry site (IRES). MYC-RIBOTAC contains a MYC mRNA binding component and a small molecule that recruits and locally activates RNAse L1. MYC-RIBOTAC reduces MYC mRNA and protein expression levels, induces cell apoptosis, and can be used for antitumor research^[1]. MYC-RIBOTAC consists of pre-miR-155 binder Anticancer agent 167 (HY-156839), RNA binder NCI-B16 (HY-156215), and Linker Amino-PEG4-alcohol (HY-W008005).

In Vitro

MYC-RIBOTAC (0-10 μM; 48 hours) decreases the abundance of MYC mRNA and protein levels in HeLa cells in a dose-dependent and RNase L dependent manner^[1].
MYC-RIBOTAC (0-10 μM; 48 hours) has antiproliferative and induce-apoptotic effects in HeLa cells and Namalwa cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HeLa cells and Namalwa cells
Concentration:

0-10 μM
Incubation Time:

48 hours
Result:

Had antiproliferative and induce-apoptotic effects in in HeLa cells.
Induced cell cycle arrest and provoked apoptosis and reduced colony formation by about 50% in Namalwa cells.

Western Blot Analysis^[1]

Cell Line:

HeLa cells
Concentration:

0-10 μM
Incubation Time:

48 hours
Result:

Decreased the abundance of MYC mRNA in HeLa cells in a dose-dependent and RNase L dependent manner, up to around 50% at a 10 μM dose with a concomitant reduction in MYC protein levels.

Chemical Information

Appearance Solid
Molecular Weight 1067.17
Formula C₅₅H₅₈N₁₀O₁₁S
Color Light yellow to yellow
SMILES

O=C(NC1=CC(NC(NC2=CC=C(C3=NCCN3)C=C2)=O)=CC(C(NCCOCCOCCOCCOC4=C(O)C=C(/C=C5SC(NC6=CC=CC=C6)=C(C(OCC)=O)C\5=O)C=C4)=O)=C1)NC7=CC=C(C8=NCCN8)C=C7
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

bioRxiv

2026 Feb 2.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (93.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.9371 mL

4.6853 mL

9.3706 mL

5 mM

0.1874 mL

0.9371 mL

1.8741 mL

10 mM

0.0937 mL

0.4685 mL

0.9371 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
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g
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tong Y, et.al. Programming inactive RNA-binding small molecules into bioactive degraders. Nature. 2023 Jun;618(7963):169-179. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.9371 mL	4.6853 mL	9.3706 mL	23.4264 mL
	5 mM	0.1874 mL	0.9371 mL	1.8741 mL	4.6853 mL
	10 mM	0.0937 mL	0.4685 mL	0.9371 mL	2.3426 mL
	15 mM	0.0625 mL	0.3124 mL	0.6247 mL	1.5618 mL
	20 mM	0.0469 mL	0.2343 mL	0.4685 mL	1.1713 mL
	25 mM	0.0375 mL	0.1874 mL	0.3748 mL	0.9371 mL
	30 mM	0.0312 mL	0.1562 mL	0.3124 mL	0.7809 mL
	40 mM	0.0234 mL	0.1171 mL	0.2343 mL	0.5857 mL
	50 mM	0.0187 mL	0.0937 mL	0.1874 mL	0.4685 mL
	60 mM	0.0156 mL	0.0781 mL	0.1562 mL	0.3904 mL
	80 mM	0.0117 mL	0.0586 mL	0.1171 mL	0.2928 mL

Keywords

100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo Dissolution Calculator
Purity & Documentation
References

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MYC-RIBOTAC

Publications Citing Use of MedChemExpress (MCE) MYC-RIBOTAC

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

MYC-RIBOTAC Related Classifications

Cat. No.: HY-153713