Antitumor agent-92
Antitumor agent-92, an Icaritin (HY-N0678) derivative, causes arrest at the G0/G1 phase in the cell cycle and induces cell apoptosis. Antitumor agent-92 has the potential for hepatocellular carcinoma (HCC) research.
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- CAS 番号: 2922842-01-9
- 分子式: C33H41NO10
- 分子量:611.68
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hep 3B2 | IC50 |
3.9 μM
Compound: 11c
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Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human Hep3B cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 36745506] |
| HepG2 | IC50 |
7.6 μM
Compound: 11c
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 36745506] |
| SMMC-7721 | IC50 |
3.1 μM
Compound: 11c
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Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human SMMC-7721 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 36745506] |
Antitumor agent-92 (compound 11c; 2-8 μM; 48 h) induces apoptosis in HepG2 and SMMC-7721 cells, especially at high concentrations[1].
Antitumor agent-92 (2-8 μM; 48 h) can induce the G0/G1 cycle arrest in HepG2 and SMMC-7721 cells[1].
Antitumor agent-92 (2-8 μM; 48 h) upregulates P21 and downregulates Cdc2 p34 and CDK4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 and SMMC-7721 cells
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Concentration:2, 4, 8 μM
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Incubation Time:48 h
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Result:Apoptotic cells were observed, as evidenced by the increasing number of detached cells and fewer HepG2 and SMMC-7721 cells.
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Cell Line:HepG2 and SMMC-7721 cells
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Concentration:2, 4, 8 μM
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Incubation Time:48 h
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Result:Led to an increased percentage of cells at the G0/G1 phase from 64.22% and 58.43% of the untreated control to 83.28% and 78.95%, respectively.
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Cell Line:HepG2 and SMMC-7721 cells
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Concentration:2, 4, 8 μM
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Incubation Time:48 h
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Result:The level of P21 was upregulated, and Cdc2 p34 and CDK4 were downregulated.
化学情報
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CAS 番号 2922842-01-9
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分子量 611.68
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分子式 C33H41NO10
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SMILES
COC1=CC=C(C=C1)C2=C(C(C3=C(C=C(C(C/C=C(C)\C)=C3O2)OCCN4CCCC4)O)=O)O[C@H]5O[C@@H]([C@H]([C@@H]([C@@H]5O)O)O)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antitumor agent-92 関連分類
HY-149063 関連分類
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