CGS 24891
CGS 24891 is an orally active 5-lipoxygenase (5-LO) inhibitor, with an IC50 value of 0.051 μM in guinea pigs and 0.11 μM in dogs. CGS 24891 inhibits the production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) from arachidonic acid. CGS 24891 weakly inhibits 12-lipoxygenase (12-LO) with an IC50 of 0.41 μM. CGS 24891 is applicable to research on inflammation and allergic reactions.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 134823-10-2
- 分子式: C18H17FN2O4
- 分子量:344.34
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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5-LO 0.051 (gui μM (IC50) |
5-LO 0.11 (dogs μM (IC50) |
12-LOX 0.41 μM (IC50) |
CGS 24891 potently inhibits 5-lipoxygenase activity in guinea pig polymorphonuclear leukocytes (PMNs) with an IC50 value of 51 nM[1].
CGS 24891 inhibits the activity of 5-lipoxygenase in canine whole blood, with an IC50 of 0.11 μM[1].
CGS 24891 inhibits 12-lipoxygenase activity in platelets with an IC50 of 0.41 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 134823-10-2
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分子量 344.34
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分子式 C18H17FN2O4
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SMILES
O=C(N(CC1=CC2=C(OC1)C=CC(OC3=CC=C(C=C3)F)=C2)O)NC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CGS 24891 関連分類
HY-182696 関連分類
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