(E/Z)-IT-603
Based on 1 Customer Validation
(E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 is also an IĸBα/c-Rel inhibitor. IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.29%
- CAS 番号: 292168-90-2
- 分子式: C11H9BrN2O3S
- 分子量:329.17
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
化学情報
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CAS 番号 292168-90-2
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性状 Solid
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分子量 329.17
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分子式 C11H9BrN2O3S
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Color Light yellow to orange
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SMILES
O=C(/C(N1)=C\C2=CC(Br)=CC(OC)=C2O)NC1=S
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 125 mg/mL (379.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Yusuke Shono, et al. A small molecule c-Rel inhibitor reduces alloactivation of T-cells without compromising anti-tumor activity. Cancer Discov. 2014 May; 4(5): 578-591. [Content Brief]
[2]. Huang X, et al. ESAT-6 protein suppresses allograft rejection by inducing CD4+Foxp3+ regulatory T cells through IκBα/cRel pathway. Front Immunol. 2025 Jan 9;15:1529226. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0379 mL | 15.1897 mL | 30.3794 mL | 75.9486 mL |
| 5 mM | 0.6076 mL | 3.0379 mL | 6.0759 mL | 15.1897 mL | |
| 10 mM | 0.3038 mL | 1.5190 mL | 3.0379 mL | 7.5949 mL | |
| 15 mM | 0.2025 mL | 1.0126 mL | 2.0253 mL | 5.0632 mL | |
| 20 mM | 0.1519 mL | 0.7595 mL | 1.5190 mL | 3.7974 mL | |
| 25 mM | 0.1215 mL | 0.6076 mL | 1.2152 mL | 3.0379 mL | |
| 30 mM | 0.1013 mL | 0.5063 mL | 1.0126 mL | 2.5316 mL | |
| 40 mM | 0.0759 mL | 0.3797 mL | 0.7595 mL | 1.8987 mL | |
| 50 mM | 0.0608 mL | 0.3038 mL | 0.6076 mL | 1.5190 mL | |
| 60 mM | 0.0506 mL | 0.2532 mL | 0.5063 mL | 1.2658 mL | |
| 80 mM | 0.0380 mL | 0.1899 mL | 0.3797 mL | 0.9494 mL | |
| 100 mM | 0.0304 mL | 0.1519 mL | 0.3038 mL | 0.7595 mL |
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