292168-90-2
292168-90-2
Chemical Structure
(E/Z)-IT-603
- CAS No.: 292168-90-2
- Formula:C11H9BrN2O3S
- Molecular Weight:329.17
IUPAC Name: (E)-5-(5-bromo-2-hydroxy-3-methoxybenzylidene)-2-thioxoimidazolidin-4-one
InChIKey: PYLYAEDUIKQBOT-XVNBXDOJSA-N
SMILES: O=C(/C(N1)=C\C2=CC(Br)=CC(OC)=C2O)NC1=S
Biological Activity: (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 is also an IĸBα/c-Rel inhibitor. IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(E/Z)-IT-603 | 99.29% | (E/Z)-IT-603 is a mixture of E-IT-603 and Z-IT-603 (IT-603). (E/Z)-IT-603 is also an IĸBα/c-Rel inhibitor. IT-603 is a c-Rel inhibitor with an IC50 of 3 μM. IT-603 has anti-tumor activity. (E/Z)-IT-603 is a promising modulator of T-cell responses in the context of graft-versus-host disease (GVHD) and malignant diseases. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.60
HY-48241WAY-616296 -
Similarity Score 0.56
HY-112197PKG drug G1 -
Similarity Score 0.55
HY-161954HDAC8-IN-12 -
Similarity Score 0.55
HY-124179IT-901 -
Similarity Score 0.54
HY-141805MHY-1685 -
Similarity Score 0.53
HY-W009732Acis-Sinapinic acid -
Similarity Score 0.53
HY-W009732RSinapinic acid (Standard) -
Similarity Score 0.53
HY-N3265Methyl sinapate -
Similarity Score 0.53
HY-N3265A(E)-Methyl sinapate -
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