PKG drug G1
Based on 2 publication(s) in Google Scholar
PKG agent G1 targets C42 of PKG Iα. PKG agent G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.
For research use only. We do not sell to patients.
- Purity: 99.11%
- CAS No.: 374703-78-3
- Formula: C13H11N3OS
- Molecular Weight:257.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) PKG drug G1
More
Biological Activity
PKG Iα[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
14 μM
Compound: 8
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Inhibitory activity against CDK4 using recombinant human cyclin D2-CDK4 complex expressed in sf9 cells
Inhibitory activity against CDK4 using recombinant human cyclin D2-CDK4 complex expressed in sf9 cells
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[PMID: 11741479] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 374703-78-3
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Appearance Solid
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Molecular Weight 257.31
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Formula C13H11N3OS
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Color Light brown to reddish brown
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SMILES
O=C(/C(N1)=C/C2=C(C)NC3=C2C=CC=C3)NC1=S
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Commun
Maturation and substrate processing topography of the Plasmodium falciparum invasion/egress protease plasmepsin X. [Abstract]2022 Aug 4;13(1):4537. PMID: 35927261 -
Solvent & Solubility
DMSO : 75 mg/mL (291.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Mice[1]
Mice constitutively expressing PKG Iα Cys42Ser are generated on a pure C57BL/6 background. Age-matched and body weight–matched WT or PKG Iα Cys42Ser KI male mice are used in all studies. Blood pressure and heart rate are assessed by radio telemetry in conscious freely moving mice. Alzet osmotic mini-pumps are used to deliver angiotensin II at 1.1 mg/kg per day in some studies. PKG drug G1 is delivered intraperitoneally (3.7-14.8 mg/kg) or orally (20 mg/kg) in some studies. To deliver PKG drug G1 orally, without stress or risk of dislodging the telemetric probe catheter, it is provided suspended in water and set in gelatin flavored with sodium saccharin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (278 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8864 mL | 19.4318 mL | 38.8636 mL | 97.1591 mL |
| 5 mM | 0.7773 mL | 3.8864 mL | 7.7727 mL | 19.4318 mL | |
| 10 mM | 0.3886 mL | 1.9432 mL | 3.8864 mL | 9.7159 mL | |
| 15 mM | 0.2591 mL | 1.2955 mL | 2.5909 mL | 6.4773 mL | |
| 20 mM | 0.1943 mL | 0.9716 mL | 1.9432 mL | 4.8580 mL | |
| 25 mM | 0.1555 mL | 0.7773 mL | 1.5545 mL | 3.8864 mL | |
| 30 mM | 0.1295 mL | 0.6477 mL | 1.2955 mL | 3.2386 mL | |
| 40 mM | 0.0972 mL | 0.4858 mL | 0.9716 mL | 2.4290 mL | |
| 50 mM | 0.0777 mL | 0.3886 mL | 0.7773 mL | 1.9432 mL | |
| 60 mM | 0.0648 mL | 0.3239 mL | 0.6477 mL | 1.6193 mL | |
| 80 mM | 0.0486 mL | 0.2429 mL | 0.4858 mL | 1.2145 mL | |
| 100 mM | 0.0389 mL | 0.1943 mL | 0.3886 mL | 0.9716 mL |
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