Elotuzumab
Based on 1 Customer Validation
Elotuzumab (HuLuc 63) is an IgG1 monoclonal antibody targeting the SLAMF7 receptor. Elotuzumab exerts antitumor activity by activating natural killer cells and inducing antibody-dependent cell-mediated cytotoxicity. Elotuzumab can be combined with Lenalidomide (HY-A0003), Dexamethasone (HY-14648), etc., for the research of tumors such as multiple myeloma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- CAS 番号: 915296-00-3
- 分子量:145.44 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
Human IgG1 kappa
Human
SLAMF7/CS1
Elotuzumab (0.1-10 μg/mL; 4-20 h) upregulates the expression of CD107a, CD69 and CD54 on NK cells, and promotes the secretion of IFN-γ and TNF-α in a co-culture system of human PBMC and OPM-2 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female BALB/c mice treated A20-hSLAMF7 cells or EG7-hSLAMF7 cells[2]
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Dosage:10 mg/kg (Elotuzumab in the form of murine IgG2a subtype)
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Administration:Intraperitoneal injection; 3 times; once every 3-4 days
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Result:Inhibited tumor growth, increased tumor-infiltrating NK cells and CD8+ T cells, and the expression of activation markers on these cells.
Promoted tumor-infiltrating NK and CD81 T-cell activation, as well as increased intratumoral cytokine and chemokine release by combination with anti-PD-1 antibody.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Immobilized Human CS1 can bind Elotuzumab. The EC50 for this effect is 20.87 ng/mL. -
Flow cytometric analysis of 1X106 MM.1S cells with Elotuzumab (HY-P9965, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
化学情報
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CAS 番号 915296-00-3
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性状 Liquid
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分子量 145.44 kDa
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Color Colorless to light yellow
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SMILES
[Elotuzumab]
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別名
HuLuc 63; PDL 063; BMS 901608
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (260 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)