Degs1 - delta(4)-desaturase, sphingolipid 1 Gene

Also Known as Degs; Des1; Mdes

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 13244

Summary

Enables retinol isomerase activity and sphingolipid delta-4 desaturase activity. Acts upstream of or within ceramide biosynthetic process and positive regulation of apoptotic process. Predicted to be located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human DEGS1 (delta 4-desaturase, sphingolipid 1). [provided by Alliance of Genome Resources, Apr 2022]

Degs1 Products (2)

mRNA Protein Name
NM_001360783.1 NP_001347712.1 sphingolipid delta(4)-desaturase DES1 isoform 2
NM_007853.5 NP_031879.1 sphingolipid delta(4)-desaturase DES1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables retinol isomerase activity IDA
IDA: Inferred from direct assay
23143414 MGI
enables sphingolipid delta-4 desaturase activity IMP
IMP: Inferred from mutant phenotype
22984457 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of or within ceramide biosynthetic process IMP
IMP: Inferred from mutant phenotype
22984457 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22984457 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingolipid delta(4)-desaturase DES1

  • degenerative spermatocyte homolog 1

  • dihydroceramide desaturase

  • dihydroceramide desaturase-1

  • retinol isomerase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-153665 Deg-1 99.45% Unkown
HY-183723 GAA-4OH Inhibitor / Unkown
HY-RS03682 DEGS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21551 Degs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28069 Degs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Degs1 NCBI NCBI:8560