GLCE - glucuronic acid epimerase Gene

Also Known as HSEPI

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 26035

About GLCE

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:69,160,635-69,272,207 (from NCBI)

This gene has 4 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in colon (RPKM 5.9), duodenum (RPKM 5.7) and 25 other tissues.

Summary

Enables calcium ion binding activity; heparosan-N-sulfate-glucuronate 5-epimerase activity; and protein homodimerization activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

GLCE Products (5)

mRNA Protein Name
NM_001324091.2 NP_001311020.1 D-glucuronyl C5-epimerase isoform 2
NM_001324092.2 NP_001311021.1 D-glucuronyl C5-epimerase isoform 3
NM_001324093.2 NP_001311022.1 D-glucuronyl C5-epimerase isoform 1
NM_001324094.2 NP_001311023.1 D-glucuronyl C5-epimerase isoform 1
NM_015554.3 NP_056369.1 D-glucuronyl C5-epimerase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables calcium ion binding IDA
IDA: Inferred from direct assay
30872481 GOA
enables heparosan-N-sulfate-glucuronate 5-epimerase activity IDA
IDA: Inferred from direct assay
15853773 GOA
enables heparosan-N-sulfate-glucuronate 5-epimerase activity IMP
IMP: Inferred from mutant phenotype
20118238 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
30872481 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in heparan sulfate proteoglycan biosynthetic process IDA
IDA: Inferred from direct assay
20118238 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLCE Protein Structure

C5-epim_C

C5-epim_C: D-glucuronyl C5-epimerase C-terminus (416 - 607)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 617 a.a.
Protein Preferred Names Protein Names

D-glucuronyl C5-epimerase

  • UDP-glucuronic acid epimerase

関連疾患

Diseases Alias
Triosephosphate Isomerase Deficiency

  • TPID

  • Triose Phosphate-Isomerase Deficiency

  • Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency

  • Tpi Deficiency

  • Triose Phosphate Isomerase Deficiency

  • Deficiency Of Phosphotriose Isomerase

  • Hereditary Nonspherocytic Hemolytic Anemia Due To Triosephosphate Isomerase Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS05467 GLCE Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus GLCE MGD MGI:2136405
Rattus norvegicus GLCE RGD RGD:1565253
Macaca mulatta GLCE VGNC VGNC:72959
Canis familiaris GLCE VGNC VGNC:41251
Bos taurus GLCE VGNC VGNC:29394
Felis catus GLCE VGNC VGNC:62573
Others GLCE NCBI