ZWILCH - zwilch kinetochore protein Gene

Also Known as KNTC1AP; hZwilch

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 55055

About ZWILCH

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,505,326-66,550,130 (from NCBI)

This gene has 14 transcripts (splice variants) and 197 orthologues. Broad expression in testis (RPKM 32.5), lymph node (RPKM 6.0) and 19 other tissues.

Summary

Involved in protein localization to kinetochore. Located in kinetochore. Part of RZZ complex. [provided by Alliance of Genome Resources, Apr 2022]

ZWILCH Products (4)

mRNA Protein Name
NM_001287821.2 NP_001274750.1 protein zwilch homolog isoform 2
NM_001287822.2 NP_001274751.1 protein zwilch homolog isoform 2
NM_001287823.2 NP_001274752.1 protein zwilch homolog isoform 2
NM_017975.5 NP_060445.3 protein zwilch homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
12686595 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
15824131 GOA
involved in protein localization to kinetochore IMP
IMP: Inferred from mutant phenotype
15824131 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of RZZ complex IDA
IDA: Inferred from direct assay
20462495 GOA
part of RZZ complex IPI
IPI: Inferred from physical interaction
25849506 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
12686595 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZWILCH Protein Structure

Zwilch

Zwilch: RZZ complex, subunit zwilch (31 - 587)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 591 a.a.
Protein Preferred Names Protein Names

protein zwilch homolog

  • Zwilch, kinetochore associated, homolog

関連疾患

Diseases Alias
Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia

  • X-Linked Dominant Chondrodysplasia, Chassaing-Lacombe Type

  • X-Linked Dominant Chondrodysplasia-Hydrocephaly-Microphthalmia Syndrome

  • CDP-PBHM

  • Chondrodysplasia, With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia
Mosaic Variegated Aneuploidy Syndrome

  • Warburton-Anyane-Yeboa Syndrome

  • Mva Syndrome

  • Mosaic Variegated Aneuplody Microcephaly Syndrome

  • Warburton Anyane Yeboa Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS16209 ZWILCH Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus ZWILCH RGD RGD:1583880
Felis catus ZWILCH VGNC VGNC:67389
Bos taurus ZWILCH VGNC VGNC:37391
Macaca mulatta ZWILCH VGNC VGNC:79496
Canis familiaris ZWILCH VGNC VGNC:48865
Mus musculus ZWILCH MGD MGI:1915264
Others ZWILCH NCBI