GSDMC - gasdermin C Gene

Also Known as MLZE

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 56169

About GSDMC

Cytogenetic location: 8q24.21 Genomic coordinates (GRCh38): 8:129,705,435-129,786,624 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 190 orthologues and 4 paralogues. Biased expression in skin (RPKM 9.5), spleen (RPKM 4.6) and 1 other tissue.

Summary

Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in defense response to bacterium and Pyroptosis. Predicted to act upstream of or within intestinal epithelial cell development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GSDMC Products (1)

mRNA Protein Name
NM_031415.3 NP_113603.1 gasdermin-C

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables wide pore channel activity IDA
IDA: Inferred from direct assay
32929201 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
32929201 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
11223543 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
32929201 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSDMC Protein Structure

Gasdermin

Gasdermin: Gasdermin family (4 - 484)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

gasdermin-C

  • melanoma-derived leucine zipper, extra-nuclear factor

Recombinant GSDMC Proteins

製品番号 製品名 アクセッション番号 純度
HY-P71649 GSDMC Protein, Human (His-SUMO) Q9BYG8 (M1-A508) ≥ 90%, as determined by reducing SDS-PAGE.

GSDMC 抗体

製品番号 製品名 アプリケーション 反応性
HY-P811373 GSDMC Antibody WB, IHC-P, IHC-F, IF-Tissue Human

関連疾患

Diseases Alias
Spinal Stenosis

  • Lumbar Spinal Stenosis

  • Cervical Spinal Stenosis

  • Spinal Stenosis Of Lumbar Region

  • Spinal Stenosis In Cervical Region

  • Spinal Canal Stenosis
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS05856 GSDMC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180786 DdBIC / Unkown
HY-RS19008 Gsdmc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25497 Gsdmc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta GSDMC VGNC VGNC:73380
Rattus norvegicus GSDMC RGD RGD:1308989
Felis catus GSDMC VGNC VGNC:68276
Canis familiaris GSDMC VGNC VGNC:49925
Bos taurus GSDMC VGNC VGNC:29674
Others GSDMC NCBI