GSDMC Antibody
(Synonyms: MLZE; GSDMC_HUMAN; GSDMC; Melanoma-derived leucine zipper-containing extranuclear factor; gasdermin C; melanoma-derived leucine zipper, extra-nuclear factor)GSDMC Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to GSDMC.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P, IHC-F, IF-Tissue
-
Reactivity :
Human
-
Formulation:
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
IHC-F
IHC-F: Immunohistochemistry-Frozen
|
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
|
|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:100-500 | 1:100-500 |
Product Details
GSDMC Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to GSDMC.
-
Host Rabbit
-
Clonality Polyclonal
-
Species ReactivityHuman
-
Observed Molecular WeightObserved band size: 47 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 58 kDa
KLH conjugated synthetic peptide derived from human GSDMC : 1-100/508
Endogenous
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
GSDMC protein serves as the precursor to the pore-forming protein, and upon cleavage, the released N-terminal moiety, known as Gasdermin-C, binds to membranes and forms pores, leading to the induction of pyroptosis. The pore-forming activity involves the homooligomerization of GSDMC within the membrane, resulting in the formation of pores with inner diameters ranging from 10 to 15 nanometers. This process is initiated by the cleavage of gasdermin-D by caspase CASP8 in response to death signals, and the subsequent movement of the cleaved protein to the plasma membrane, where it exhibits strong binding to the inner leaflet lipids, ultimately triggering pyroptosis.
-
Subcellular Localization
Gasdermin-C: Cytoplasm, cytosol; Gasdermin-C, N-terminal: Cell membrane
-
Expression
Tissue specificity: Expressed mainly in trachea and spleen. In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium.
Induction: Expression in induced by STAT3 and CD274/PD-L1 in response to hypoxia. -
Isoforms & Post-Translational Modification
Cleavage by CASP8 relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-C, N-terminal) that initiates pyroptosis. Palmitoylated.
-
Subunit
Gasdermin-C, N-terminal: Homooligomer; homooligomeric ring-shaped pore complex containing 27-28 subunits when inserted in the membrane.
-
SwissProt ID
-
Synonyms
MLZE; GSDMC_HUMAN; GSDMC; Melanoma-derived leucine zipper-containing extranuclear factor; gasdermin C; melanoma-derived leucine zipper, extra-nuclear factor
-
Research Field
Cell Biology
Documentation
Powered by Bioz
