GSDMC - gasdermin C Gene

Also Known as MLZE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56169

About GSDMC

Cytogenetic location: 8q24.21 Genomic coordinates (GRCh38): 8:129,705,435-129,786,624 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 190 orthologues and 4 paralogues. Biased expression in skin (RPKM 9.5), spleen (RPKM 4.6) and 1 other tissue.

Summary

Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in defense response to bacterium and Pyroptosis. Predicted to act upstream of or within intestinal epithelial cell development. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GSDMC Products (1)

mRNA Protein Name
NM_031415.3 NP_113603.1 gasdermin-C

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables wide pore channel activity IDA
IDA: Inferred from direct assay
32929201 GOA
Biological Process GO Annotation Evidence References Source
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
32929201 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11223543 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
32929201 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSDMC Protein Structure

Gasdermin

Gasdermin: Gasdermin family (4 - 484)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

gasdermin-C

  • melanoma-derived leucine zipper, extra-nuclear factor

Recombinant GSDMC Proteins

Cat. No. Product Name Accession Purity
HY-P71649 GSDMC Protein, Human (His-SUMO) Q9BYG8 (M1-A508) ≥ 90%, as determined by reducing SDS-PAGE.

GSDMC Antibodies

Cat. No. Product Name Application Reactivity
HY-P811373 GSDMC Antibody WB, IHC-P, IHC-F, IF-Tissue Human

Related Diseases

Diseases Alias
Spinal Stenosis

  • Lumbar Spinal Stenosis

  • Cervical Spinal Stenosis

  • Spinal Stenosis Of Lumbar Region

  • Spinal Stenosis In Cervical Region

  • Spinal Canal Stenosis
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05856 GSDMC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180786 DdBIC / Unkown
HY-RS19008 Gsdmc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25497 Gsdmc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GSDMC VGNC VGNC:73380
Rattus norvegicus GSDMC RGD RGD:1308989
Felis catus GSDMC VGNC VGNC:68276
Canis familiaris GSDMC VGNC VGNC:49925
Bos taurus GSDMC VGNC VGNC:29674
Others GSDMC NCBI