SHD - Src homology 2 domain containing transforming protein D Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 56961

About SHD

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,279,069-4,290,722 (from NCBI)

This gene has 5 transcripts (splice variants), 269 orthologues and 3 paralogues. Biased expression in brain (RPKM 6.5), heart (RPKM 2.0) and 5 other tissues.

Summary

Predicted to enable phosphotyrosine residue binding activity. [provided by Alliance of Genome Resources, Apr 2022]

SHD Products (2)

mRNA Protein Name
NM_001372011.1 NP_001358940.1 SH2 domain-containing adapter protein D
NM_020209.4 NP_064594.3 SH2 domain-containing adapter protein D

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
24728074 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHD Protein Structure

SH2

SH2: SH2 domain (240 - 316)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

SH2 domain-containing adapter protein D

  • src homology 2 domain-containing transforming protein D

SHD Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SHD Q96IW2 MET Homo sapiens P08581
FPS
24728074
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Fetal Encasement Syndrome

  • Cocoon Syndrome

  • COCOS

  • Fetal Diseases
Branched-Chain Keto Acid Dehydrogenase Kinase Deficiency

  • BCKDKD

  • Branched-Chain Ketoacid Dehydrogenase Kinase Deficiency

  • Bckdk Deficiency

  • Autism-Epilepsy Syndrome Due To Branched Chain Ketoacid Dehydrogenase Kinase Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12861 SHD Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus SHD VGNC VGNC:34594
Rattus norvegicus SHD RGD RGD:1590885
Mus musculus SHD MGD MGI:1099461
Felis catus SHD VGNC VGNC:65121
Macaca mulatta SHD VGNC VGNC:77353
Canis familiaris SHD VGNC VGNC:46145
Others SHD NCBI