G6PC2 - glucose-6-phosphatase catalytic subunit 2 Gene

Also Known as IGRP

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 57818

About G6PC2

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:168,901,291-168,910,000 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 166 orthologues and 2 paralogues. Biased expression in pancreas (RPKM 3.9), testis (RPKM 0.4) and 1 other tissue.

Summary

This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These Enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

G6PC2 Products (2)

mRNA Protein Name
NM_001081686.2 NP_001075155.1 glucose-6-phosphatase 2 isoform 2
NM_021176.3 NP_066999.1 glucose-6-phosphatase 2 isoform 1

G6PC2 Protein Structure

PAP2

PAP2: PAP2 superfamily (58 - 194)

  • 0
  • 100
  • 200
  • 300
  • 355 a.a.
Protein Preferred Names Protein Names

glucose-6-phosphatase 2

  • G-6-Pase 2

関連疾患

Diseases Alias
Heart Defects, Congenital, And Other Congenital Anomalies

  • Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome

  • Pancreatic Agenesis And Congenital Heart Defects

  • HDCA

  • PACHD

  • Congenital Pancreatic Hypoplasia With Diabetes Mellitus And Congenital Heart Disease

  • Yorifuji-Okuno Syndrome

  • Yorifuji Okuno Syndrome

  • Pancreatic Hypoplasia, Congenital, With Diabetes Mellitus And Congenital Heart Disease

  • Congenital Heart Defects And Other Congenital Anomalies

  • Hereditary Pancreatic Hypoplasia, Diabetes Mellitus And Congenital Heart Disease

  • Congenital Pancreatic Agenesis With Diabetes Mellitus And Congenital Heart Disease

  • Heart Disease, Congenital, And Other Congenital Anomalies
Type 1 Diabetes Mellitus 7

  • Diabetes Mellitus, Insulin-Dependent, 7

  • Iddm7

  • Insulin-Dependent Diabetes Mellitus 7

  • T1D7
Glycogen Storage Disease

  • Glycogenosis

  • Glycogenoses

  • Gsd

  • Storage Disease, Glycogen

  • Gsd - [Glycogen Storage Disease]

  • Glycogen Thesaurismosis

  • Diffuse Glycogenosis

  • Generalised Glycogen Storage Disease

  • Generalised Glycogenosis

  • Generalised Glycogen Storage Disease Of Infants

  • Glycogen Synthase Deficiency
Type 1 Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetes Mellitus Type 1

  • IDDM

  • Type 1 Diabetes

  • Insulin-Dependent Diabetes Mellitus

  • T1D

  • Juvenile-Onset Diabetes

  • Jod

  • Diabetes Mellitus, Type 1

  • Diabetes Mellitus, Insulin-Dependent-1

  • Type I Diabetes Mellitus

  • Autoimmune Diabetes

  • Juvenile Diabetes

  • Juvenile-Onset Diabetes Mellitus

  • Diabetes, Insulin Dependent

  • Insulin-Dependent Diabetes Mellitus-1

  • Diabetes Mellitus Insulin-Dependent

  • Diabetes Autoimmune

  • Diabetes Mellitus, Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 1, Susceptibility To

  • Diabetes Type 1

  • Type I Diabetes

  • Diabetes, Autoimmune

  • T1dm - [Type 1 Diabetes Mellitus]

  • Iddm - [Insulin Dependent Diabetes Mellitus]

  • Type 1 Iddm

  • Juvenile Diabetes Mellitus Without Compications

  • Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

  • Juvenile-Onset Diabetes Mellitus Without Compications

  • Ketosis-Prone Diabetes Mellitus Without Compications

  • Juvenile-Onset-Type Diabetes Mellitus Without Compications
Type 1 Diabetes Mellitus 5

  • Diabetes Mellitus, Insulin-Dependent, 5

  • Latent Autoimmune Diabetes In Adults

  • IDDM5

  • Insulin-Dependent Diabetes Mellitus 5

  • T1D5

  • Lada

  • Type 1.5 Diabetes

  • Diabetes Mellitus, Insulin-Dependent, Type 5
X-Linked Immunodeficiency 74

  • Immunodeficiency 74, Covid-19-Related, X-Linked

  • Imd74

  • Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection

  • Tlr7 Deficiency

  • X-Linked Immunodeficiency 74,Covid-19-Related
Pancreatic Cystadenoma

  • Cystadenoma Of Pancreas
Glycogen Storage Disease Ia

  • Von Gierke Disease

  • Glycogen Storage Disease Type I

  • Glycogen Storage Disease I

  • Hepatorenal Form Of Glycogen Storage Disease

  • Hepatorenal Glycogenosis

  • Glucose-6-Phosphatase Deficiency

  • Glycogen Storage Disease, Type I

  • Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia

  • GSD1A

  • Gsd1

  • Von Gierke'S Disease

  • Glycogen Storage Disease Type 1a

  • Glycogen Storage Disease 1a

  • Glucose-6-Phosphate Transport Defect

  • Gsd Ia

  • Deficiency Of Glucose-6-Phosphatase

  • Glycogenosis Type I

  • Glucose-6-Phosphatase Deficiency Glycogen Storage Disease

  • Glycogenosis Type 1

  • Glucose-6-Phosphate Deficiency

  • Gsd I

  • Gsd Type I

  • G6p Deficiency Type 1a

  • Gsd Due To G6p Deficiency Type 1a

  • Gsd Due To G6p Deficiency Type Ia

  • Gsd Type 1a

  • Gsdia

  • Glycogen Storage Disease Due To G6p Deficiency Type Ia

  • Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a

  • Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia

  • Glycogenosis Type Ia

  • Gsd-Ia

  • Storage Disease, Glycogen, Type 1a

  • Glycogen Storage Disease Type Ia
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Permanent Neonatal Diabetes Mellitus

  • Pndm

  • Permanent Diabetes Mellitus Of Infancy

  • Pdmi

  • Neonatal Diabetes Mellitus, Permanent
Diabetes Mellitus

  • Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS05192 G6PC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus G6PC2 VGNC VGNC:29179
Felis catus G6PC2 VGNC VGNC:62409
Mus musculus G6PC2 MGD MGI:1277193
Canis familiaris G6PC2 VGNC VGNC:41041
Rattus norvegicus G6PC2 RGD RGD:69398
Macaca mulatta G6PC2 VGNC VGNC:84884
Others G6PC2 NCBI