VKORC1 - vitamin K epoxide reductase complex subunit 1 Gene

Also Known as VKOR; MST134; MST576; VKCFD2; EDTP308

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 79001

About VKORC1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,090,854-31,094,797 (from NCBI)

This gene has 8 transcripts (splice variants), 185 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in liver (RPKM 74.3), fat (RPKM 26.7) and 25 other tissues.

Summary

This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting Enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

VKORC1 Products (3)

mRNA	Protein	Name
NM_001311311.2	NP_001298240.1	vitamin K epoxide reductase complex subunit 1 isoform 3 precursor
NM_024006.6	NP_076869.1	vitamin K epoxide reductase complex subunit 1 isoform 1 precursor
NM_206824.3	NP_996560.1	vitamin K epoxide reductase complex subunit 1 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	22046132	GOA
enables vitamin-K-epoxide reductase (warfarin-insensitive) activity	IDA IDA: Inferred from direct assay	33154105	GOA
enables vitamin-K-epoxide reductase (warfarin-sensitive) activity	IDA IDA: Inferred from direct assay	16270630	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in blood coagulation	IMP IMP: Inferred from mutant phenotype	16270630	GOA
involved in peptidyl-glutamic acid carboxylation	IMP IMP: Inferred from mutant phenotype	20978134	GOA
involved in vitamin K metabolic process	IDA IDA: Inferred from direct assay	16270630	GOA
involved in xenobiotic metabolic process	IMP IMP: Inferred from mutant phenotype	21127708	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	22923610	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VKORC1 Protein Structure

VKOR

0
100
163 a.a.

Protein Preferred Names	Protein Names
vitamin K epoxide reductase complex subunit 1	phylloquinone epoxide reductase

VKORC1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	VKORC1	Q9BQB6	SDC3	Homo sapiens	A0A0S2Z4U3	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	SDC3	Homo sapiens	A0A0S2Z4U3	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	RMDN3	Homo sapiens	Q96TC7	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	RMDN3	Homo sapiens	Q96TC7	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	TMPRSS2	Homo sapiens	O15393-2	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	TMPRSS2	Homo sapiens	O15393-2	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	FAM210B	Homo sapiens	Q96KR6	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	FAM210B	Homo sapiens	Q96KR6	Y2H Array	32296183
Cross	VKORC1	Q9BQB6	ORF7a	Human SARS coronavirus	Q19QW4	Lumier	22046132
Cross	VKORC1	Q9BQB6	ORF7a	Human SARS coronavirus	Q19QW4	Y2H Pooling	22046132
Intra	VKORC1	Q9BQB6	MANBAL	Homo sapiens	Q9NQG1	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	MANBAL	Homo sapiens	Q9NQG1	Validated Y2H	32296183
Intra	VKORC1	Q9BQB6	MANBAL	Homo sapiens	Q9NQG1	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	VKORC1	Q9BQB6	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	SLC7A14	Homo sapiens	Q8TBB6	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	SLC7A14	Homo sapiens	Q8TBB6	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	VKORC1	Q9BQB6	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	VKORC1	Q9BQB6	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 2	VKCFD2 Combined Deficiency Of Vitamin K-Dependent Clotting Factors 2 Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, Type 2
Coumarin Resistance	Warfarin Resistance Warfarin Sensitivity Coumadin Sensitivity Warfarin Response Poor Metabolism Of Coumarin Coumarin, Poor Metabolism Of CMRES
Hereditary Combined Deficiency Of Vitamin K-Dependent Clotting Factors	Hereditary Combined Deficiency Of Factors Ii, Vii, Ix And X Vkcfd
Atrial Fibrillation	A-Fib Fibrillation, Atrial Af - [Atrial Fibrillation] Rapid Atrial Fibrillation A Fib - [Atrial Fibrillation]
Aortic Dissection
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 1	VKCFD1 Combined Deficiency Of Vitamin K-Dependent Clotting Factors 1 Vitamin K-Dependent Coagulation Defect Multiple Coagulation Factor Deficiency Iii Mcfd3 Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, Type 1 Vkcfd Familial Multiple Coagulation Factor Deficiency Iii Fmfd Iii Factors Ii, Vii, Ix, And X, Combined Deficiency Of Glutamic Acid, Deficient Gamma-Carboxylation Of
Thrombosis	Thrombosis Of Blood Vessel
Budd-Chiari Syndrome	Hepatic Vein Thrombosis Chiari Syndrome BDCHS Membranous Obstruction Of The Inferior Vena Cava Budd-Chiari Syndrome, Somatic Movc Budd-Chiari Syndrome, Susceptibility To, Somatic Budd-Chiari Syndrome, Susceptibility To Membranous Obstruction Of Inferior Vena Cava Hepatic Vein Block Obstruction Of Hepatic Veins Hepatic Vein Obstruction Hepatic Venous Block
Pseudoxanthoma Elasticum	PXE Gronblad-Strandberg Syndrome Pseudoxanthoma Elasticum, Modifier Of Severity Of Gronblad-Strandberg-Touraine Syndrome Gronblad Strandberg Syndrome Groenblad-Strandberg Syndrome Nevus Elasticus Pxe - [Pseudoxanthoma Elasticum]
Vitamin K Deficiency Bleeding	Vitamin K Deficiency Deficiency Of Vitamin K Vitamin K Vitamin K Deficiency Hemorrhagic Disease
Retinal Vein Occlusion	Occlusion, Of Retinal Vein
Abacavir Allergy	Abc Allergy
Factitious Disorder	Munchausen Syndrome Factitious Disorders Münchausen Syndrome
Thiopurines, Poor Metabolism Of, 1	Thiopurine S-Methyltransferase Deficiency Tpmt Deficiency Thiopurine Methyltransferase Deficiency Thiopurine S Methyltranferase Deficiency THPM1 Tpmtd Poor Metabolism Of Thiopurines-1 6-Mercaptopurine Sensitivity Thiopurines, Poor Metabolism Of Poor Metabolism Of Thiopurines
Haverhill Fever	Streptobacillosis Streptobacillary Rat-Bite Fever Streptobacillary Fever Rat-Bite Fever Due To Streptobacillus Moniliformis Erythema Arthriticum Epidemicum Epidemic Arthritic Erythema
Angioid Streaks
Pulmonary Artery Disease	Abnormality Of The Pulmonary Artery
Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Drug-Induced Stevens Johnson Syndrome Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum Susceptibility To Severe Cutaneous Adverse Reaction Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Lyell'S Syndrome Lyell Syndrome Severe Cutaneous Adverse Reaction, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced Stevens-Johnson Syndrome, Susceptibility To Toxic Epidermal Necrolysis, Susceptibility To Sjs/Ten Susceptibility To Severe Cutaneous Adverse Reaction Ity To Mycoplasma-Induced Stevens Johnson Syndrome Dermatostomatitis, Stevens Johnson Type Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum Sjs-Ten Toxic Epidermolysis SJS Dermatostomatitis Stevens Johnson Type Ten Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis] Ten - [Toxic Epidermal Necrolysis]
Heart Conduction Disease	Conduction Disorder Of The Heart Heart Rhythm Disease
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Phase
HY-14854A	Tecarfarin sodium	Inhibitor	/	Phase 3
HY-14854R	Tecarfarin (Standard)	Antagonist	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS15659	VKORC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15660	VKORC1L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-14854S	Tecarfarin-13C,d3	Antagonist	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	VKORC1	VGNC	VGNC:106436
Rattus norvegicus	VKORC1	RGD	RGD:1303107
Canis familiaris	VKORC1	VGNC	VGNC:54091
Mus musculus	VKORC1	MGD	MGI:106442
Others	VKORC1	NCBI