GPAT3 - glycerol-3-phosphate acyltransferase 3 Gene

Also Known as MAG1; AGPAT8; AGPAT9; AGPAT10; AGPAT 10; HMFN0839; LPAAT-theta

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 84803

About GPAT3

Cytogenetic location: 4q21.23 Genomic coordinates (GRCh38): 4:83,535,587-83,605,875 (from NCBI)

This gene has 8 transcripts (splice variants), 144 orthologues and 4 paralogues. Broad expression in kidney (RPKM 23.1), duodenum (RPKM 10.2) and 14 other tissues.

Summary

This gene encodes a member of the lysophosphatidic acid Acyltransferase protein family. The encoded protein is an enzyme which catalyzes the conversion of glycerol-3-phosphate to lysophosphatidic acid in the synthesis of triacylglycerol. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]

GPAT3 Products (3)

mRNA Protein Name
NM_001256421.1 NP_001243350.1 glycerol-3-phosphate acyltransferase 3
NM_001256422.1 NP_001243351.1 glycerol-3-phosphate acyltransferase 3
NM_032717.5 NP_116106.2 glycerol-3-phosphate acyltransferase 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
IDA: Inferred from direct assay
19318427 GOA
NOT enables glycerol-3-phosphate O-acyltransferase activity IDA
IDA: Inferred from direct assay
19318427 GOA
enables glycerol-3-phosphate O-acyltransferase activity IDA
IDA: Inferred from direct assay
17170135 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in regulation of TOR signaling IDA
IDA: Inferred from direct assay
17002884 GOA
involved in triglyceride biosynthetic process IDA
IDA: Inferred from direct assay
17170135 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
17170135 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
17002884 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPAT3 Protein Structure

Acyltransferase

Acyltransferase: Acyltransferase (210 - 331)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 434 a.a.
Protein Preferred Names Protein Names

glycerol-3-phosphate acyltransferase 3

  • 1-AGP acyltransferase 9

関連疾患

Diseases Alias
Congenital Generalized Lipodystrophy

  • Berardinelli-Seip Congenital Lipodystrophy

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome

  • Bscl

  • Generalized Lipodystrophy

  • Lipodystrophy, Congenital Generalized

  • Seip Syndrome

  • Total Lipodystrophy

  • Cgl

  • Lipoatrophic Diabetes

  • Lipodystrophy, Generalized, Congenital

  • Familial Generalized Lipodystrophy

  • Congenital Generalized Lipodystrophy Type 2

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Lipodystrophy, Congenital Generalized, Type 2

  • Congenital Generalized Lipodystrophy Type 2

  • CGL2

  • Berardinelli-Seip Congenital Lipodystrophy Type 2

  • Berardinelli-Seip Syndrome

  • Brunzell Syndrome Bscl2-Related

  • Total Lipodystrophy And Acromegaloid Gigantism

  • Berardinelli-Seip Congenital Lipodystrophy, Type 2

  • Seip Syndrome

  • Berardinelli Syndrome

  • Lipodystrophy, Total, And Acromegaloid Gigantism

  • Lipoatrophic Diabetes, Congenital

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 2

  • Brunzell Syndrome, Bscl2-Related

  • Congenital Lipoatrophic Diabetes

  • Congenital Generalized Lipodystrophy 2

  • Lipoatrophic Diabetes

  • Lipodystrophy Berardinelli Type

  • Familial Generalized Lipodystrophy

  • Lipoatrophic Diabetes Mellitus

  • Familial Partial Lipodystrophy, Type 2
Complete Generalized Lipodystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS05617 GPAT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20414 Gpat3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26923 Gpat3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus GPAT3 VGNC VGNC:29513
Canis familiaris GPAT3 VGNC VGNC:41363
Felis catus GPAT3 VGNC VGNC:62654
Macaca mulatta GPAT3 VGNC VGNC:106586
Rattus norvegicus GPAT3 RGD RGD:1565703
Mus musculus GPAT3 MGD MGI:3603816
Others GPAT3 NCBI