Idebenone-SS-20
Idebenone-SS-20 (Idebenone-2S-FrFK-NH2) is a Idebenone (HY-N0303) derivative conjugated to the mitochondria-targeting peptide SS-20. Idebenone-SS-20 shows neuroprotective and anti-inflammatory effects. Idebenone-SS-20 can preserve mitochondrial membrane potential, enhance ATP production, reduce ROS accumulation, maintain mitochondrial morphology and elevate NAD+/NADH ratio. Idebenone-SS-20 confers robust neuroprotection in a murine model of transient middle cerebral artery occlusion. Idebenone-SS-20 can be used for the research of cerebral.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C55H81N9O11S2
- 分子量:1108.42
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Idebenone-SS-20 (Compound W1a) (0.625-5 μM; 24 h) protects HT22 hippocampal neuronal cells from glutamate-induced injury with an EC50 of 0.713 μM and has an IC50 of 68.4 μM for cytotoxicity[1].
Idebenone-SS-20 (5 μM; 12 h) restores ATP production, protects mitochondrial morphology, reduces superoxide production, and restores membrane potential in glutamate-injured HT22 hippocampal neuronal cells more effectively than Idebenone (HY-N0303)[1].
Idebenone-SS-20 (10 μM; 24 h) inhibits LPS (HY-D1056)-induced inflammation in BV2 microglial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:BV2 microglial cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Significantly inhibited LPS-induced upregulation of Il6, Tnf, and Il1b mRNA levels (with greater efficacy than idebenone) and preserved mitochondrial length and morphology.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J mice (male, 8-10 weeks, 22 ± 2 g, transient middle cerebral artery occlusion)[1]
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Dosage:20 mg/kg
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Administration:I.p.; twice (immediately after surgery and at reperfusion onset)
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Result:Significantly reduced cerebral infarct volume and suppressed neuronal death.
Increased 7-day survival rate and improved neurological recovery as measured by higher Garcia scores and longer rotarod latencies.
Restored mitochondrial gene expression (mitochondrial respiratory chain complex I assembly, electron transport chain activity, proton-driven ATP synthesis pathways).
Elevated NAD+/NADH ratio and ATP levels in brain tissue and reduced ROS accumulation.
Attenuated mitochondrial structural damage (swelling, cristae disintegration) and suppressed pro-inflammatory pathways (IL-17, NF-κB, TNF signaling) and glial (microglial, astrocytic) activation.
化学情報
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分子量 1108.42
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分子式 C55H81N9O11S2
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SMILES
COC1=C(OC)C(C(CCCCCCCCCCOC(CCSSCCC(N[C@H](C(N[C@H](CCCNC(N)=N)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=C(C)C1=O)=O
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別名
Idebenone-2S-FrFK-NH2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Idebenone-SS-20 関連分類
HY-181124 関連分類
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