MDI-117740
MDI-117740 is a dual LIMK1/2 inhibitor. MDI-117740 shows effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells. MDI-117740 exerts significant anti-migratory activity in MDA-MB-231 cells. MDI-117740 can be used for the study of cancers and neurodegenerative disorders.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C24H24N4O2
- 分子量:400.47
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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LIMK1 7.80 (pKd) |
LIMK2 7.12 (pKd) |
LIMK1 6.73 (pIC50) |
LIMK2 7.18 (pIC50) |
MDI-117740 exhibits potent binding affinity to LIMK1 (pKd = 7.80) and LIMK2 (pKd = 7.12) as well as effective cellular target engagement with LIMK1 (pIC50 = 6.73) and LIMK2 (pIC50 = 7.18) in HEK293 cells[1].
MDI-117740 (2 h) potently inhibits cofilin phosphorylation (p-cofilin) in SH-SY5Y cells, with a pIC50 value of 6.89[1].
MDI-117740 (0.25-3 μM, 48 h) exerts significant anti-migratory activity in MDA-MB-231 cells via wound healing assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 400.47
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分子式 C24H24N4O2
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SMILES
O=C(C1=C(CCN2[C@H](C3CC3)C4=CC=CC=C4)C(C2=O)=NN1CC5=CC=CC=C5)N
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MDI-117740 関連分類
HY-175656 関連分類
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