PPADS (tetrasodium)
Based on 10 publication(s) in Google Scholar
PPADS tetrasodiuma is a non-selective P2X receptor antagonist. PPADS tetrasodiuma blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. PPADS tetrasodiuma blocks native P2Y2-like (IC50~0.9 mM) and recombinant P2Y4 (IC50~15 mM) receptors. PPADS tetrasodiuma is an inhibitor of the reverse mode of the Na/Ca2+ exchanger in guinea pig airway smooth muscle.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.9%
- CAS 番号: 192575-19-2
- 分子式: C14H10N3Na4O12PS2
- 分子量:599.30
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 PPADS tetrasodium
More- Mil Med Res. 2024 Jun 27;11(1):41. [Abstract]
- Mol Psychiatry. 2026 Mar 27. [Abstract]
- J Med Chem. 2025 Apr 17. [Abstract]
- Int Immunopharmacol. 2025 Sep 6:165:115494. [Abstract]
- ACS Chem Neurosci. 2025 Feb 5;16(3):374-383. [Abstract]
- J Biol Chem. 2021 Oct;297(4):101166. [Abstract]
- J Endocrinol Invest. 2025 Feb;48(2):317-332. [Abstract]
- Pharmacol Biochem Behav. 2025 Dec:257:174114. [Abstract]
- bioRxiv. 2024 November 03.
- bioRxiv. 2023 Sep 17.
P2X Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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p2x1 Receptor |
PPADS tetrasodiuma (1-30 μM; 10-50 minutes) inhibits Na+/Ca2+ exchanger reverse mode (NCXREV) in a time- and concentration dependent manner[2].
PPADS tetrasodiuma is effective at other native and recombinant P2XRs. At human P2XRs sensitivity to PPADS tetrasodiuma depended on the subtype and is highest at the hP2X1, -2, -3, -5, and -7Rs with an IC50 of ~1-3 and ~30 μM for the hP2X4R[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley ratsweighing 160 to 200 g (anti-Thy1 disease mode)[4]
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Dosage:15 mg/100g BW, 30 mg/100g BW, 60 mg/100g BW
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Administration:i.p.; every 12 hours for 8 days (the first PPADS injection was administered 60 minutes after disease induction, and the loading dose always contained double the amount of PPADS compared to the following injections.)
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Result:Specifically and dose-dependently reduced early (day 3) glomerular mesangial cell proliferation without altering proliferation of non-MC.
化学情報
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CAS 番号 192575-19-2
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性状 Solid
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分子量 599.30
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分子式 C14H10N3Na4O12PS2
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Color Orange to red
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SMILES
O=S(C1=CC=C(/N=N/C2=NC(C)=C(O)C(C=O)=C2COP(O[Na])(O[Na])=O)C(S(=O)(O[Na])=O)=C1)(O[Na])=O
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別名
PPADS四ナトリウム塩
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (10)
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Journal Impact Factor
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Most Recent
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Mil Med Res
PANX1-mediated ATP release confers FAM3A's suppression effects on hepatic gluconeogenesis and lipogenesis. [Abstract]2024 Jun 27;11(1):41. PMID: 38937853 -
Mol Psychiatry
ATP release from the amygdala-prefrontal pathway regulates vulnerability to social stress in male mice. [Abstract]2026 Mar 27. PMID: 41896365 -
J Med Chem
A Novel Compound 3a-M1, from Metabolites of Sinomenine Derivative 3a, Exerts Potent Anti-Aplastic Anemia Activity via IP3R/ORAI-Mediated CTL Ferroptosis. [Abstract]2025 Apr 17. PMID: 40243551 -
Int Immunopharmacol
The immunoregulator β-glucan produces antidepressant effects through microglia-mobilized astrocytic P2Y1R-BDNF signaling in the dentate gyrus. [Abstract]2025 Sep 6:165:115494. PMID: 40915186 -
ACS Chem Neurosci
2025 Feb 5;16(3):374-383. PMID: 39800970 -
J Biol Chem
Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid. [Abstract]2021 Oct;297(4):101166. PMID: 34487763 -
J Endocrinol Invest
2025 Feb;48(2):317-332. PMID: 39527372 -
Pharmacol Biochem Behav
Intranasal LAG3 antibody infusion induces microglia-dependent antidepressant effect by mobilizing astrocytic P2Y1R-mediated BDNF synthesis in the hippocampus. [Abstract]2025 Dec:257:174114. PMID: 41106438 -
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溶剤 & 溶解度
H2O : 50 mg/mL (83.43 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
[1]. Flores-Soto E, et al. PPADS, a P2X receptor antagonist, as a novel inhibitor of the reverse mode of the Na⁺/Ca²⁺ exchanger in guinea pig airway smooth muscle. Eur J Pharmacol. 2012 Jan 15;674(2-3):439-44. [Content Brief]
[2]. Huo H, et al. Mapping the binding site of the P2X receptor antagonist PPADS reveals the importance of orthosteric site charge and the cysteine-rich head region. J Biol Chem. 2018 Aug 17;293(33):12820-12831. [Content Brief]
[3]. Einfluss von ATP und seinen Derivaten auf die Aktivierung von Monozyten.
[4]. Rost S, et al. P2 receptor antagonist PPADS inhibits mesangial cell proliferation in experimental mesangialproliferative glomerulonephritis. Kidney Int. 2002 Nov;62(5):1659-71. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.6686 mL | 8.3431 mL | 16.6861 mL | 41.7153 mL |
| 5 mM | 0.3337 mL | 1.6686 mL | 3.3372 mL | 8.3431 mL | |
| 10 mM | 0.1669 mL | 0.8343 mL | 1.6686 mL | 4.1715 mL | |
| 15 mM | 0.1112 mL | 0.5562 mL | 1.1124 mL | 2.7810 mL | |
| 20 mM | 0.0834 mL | 0.4172 mL | 0.8343 mL | 2.0858 mL | |
| 25 mM | 0.0667 mL | 0.3337 mL | 0.6674 mL | 1.6686 mL | |
| 30 mM | 0.0556 mL | 0.2781 mL | 0.5562 mL | 1.3905 mL | |
| 40 mM | 0.0417 mL | 0.2086 mL | 0.4172 mL | 1.0429 mL | |
| 50 mM | 0.0334 mL | 0.1669 mL | 0.3337 mL | 0.8343 mL | |
| 60 mM | 0.0278 mL | 0.1391 mL | 0.2781 mL | 0.6953 mL | |
| 80 mM | 0.0209 mL | 0.1043 mL | 0.2086 mL | 0.5214 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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