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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
TIMPs
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "TIMPs" in MCE Product Catalog:
4
4 Cited Publications
製品番号: HY-154919
純度: 99.52%
Target:
研究分野:
DC-Y13-27 is a DC-Y13 derivative and YTHDF2 inhibitor (KD: 37.9 μM). DC-Y13-27 inhibits YTHDF2, restores FOXO3 and TIMP1 protein levels, and reduces MMP1/3/7/9 expression. DC-Y13-27 induces Pyroptosis and increases IL-1β secretion. DC-Y13-27 reduces intervertebral disc degeneration and enhances the response to radiotherapy in colon cancer and melanoma. DC-Y13-27 has antitumor activity against breast cancer .
1
1 Cited Publications
Target:
研究分野:
FXR agonist 3 is an anti-NASH agent, acting by activating FXR. FXR agonist 3 inhibits COL1A1, TGF-β1, α-SMA and TIMP1 expression with anti-fibrogenic activity. FXR agonist 3 significantly reduces liver steatosis and inflammation, improves liver fibrosis level .
製品番号: HY-W075770
CAS 番号: 1313-99-1
別名: Nickel monoxide
Target:
Environmental Pollutants Apoptosis Reactive Oxygen Species (ROS) Caspase TGF-beta/Smad p38 MAPK Akt PI3K
研究分野:
Nickel(II) oxide (nickel monoxide) is a chemical warfare agent that can enter the body through the respiratory tract and other routes, distributing to organs such as the lungs and testes. The nanoparticle form of nickel(II) oxide (NiO NPs) exhibits antibacterial, anti-leishmanial, anti-diabetic, and anti-cancer activities. NiO NPs can be activated by ultraviolet and visible light, generating reactive oxygen species (ROS). Nickel(II) oxide induces oxidative stress by generating reactive oxygen species, activating the TGF-β1-mediated MAPK and PI3K/AKT pathways, disrupting the MMPs/TIMPs balance, and upregulating the expression of inflammatory factors (IL-1β, IL-6) and apoptosis-related molecules (Bax, caspase-3, p53), while inhibiting the activity of the anti-apoptotic molecule Bcl-2. Nickel(II) oxide induces cytotoxicity, promotes fibrosis, triggers inflammatory responses, and causes apoptosis. Nickel(II) oxide can be applied in research on the safety assessment of nanomaterials, such as in the context of pulmonary fibrosis and reproductive system toxicity .
MPT0B390 is an arylsulfonamide-based derivative with potent HDAC inhibitory ability. MPT0B390, TIMP3 inducer, inhibits tumor growth, metastasis and angiogenesis. MPT0B390 shows antiproliferative activity against human colon cancer cell line HCT116 with the GI50 of 0.03 μM .
製品番号: HY-W012856
CAS 番号: 620-14-4
別名: 3-Methylethylbenzene
Category:
製品番号: HY-178477
LIFR/GPBAR1 modulator 1 is an orally active, potent GPBAR1 agonist (EC50 = 0.2 μM) and LIFR inhibitor (IC50 = 7.9 μM). LIFR/GPBAR1 modulator 1 upregulates leukaemia inhibitory factor (LIF)-mediated mRNA expression of LIFR and GPBAR1 and significantly reduces the expression of pro-fibrosis markers (COL1A1, ASMA, and TGFβ), and reduces TIMP1 expression and increases MMP9 expression. LIFR/GPBAR1 modulator 1 can be used for the study of human fibrotic disorders .
製品番号: HY-P4890
CAS 番号: 1158181-62-4
製品番号: HY-RS14538
Target:
研究分野:
TIMP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TIMP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS14539
Target:
研究分野:
TIMP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TIMP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS14540
Target:
研究分野:
TIMP3 Human Pre-designed siRNA Set A contains three designed siRNAs for TIMP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS14541
Target:
研究分野:
TIMP4 Human Pre-designed siRNA Set A contains three designed siRNAs for TIMP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS18302
Target:
研究分野:
Timp3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Timp3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS20115
Target:
研究分野:
Timp4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Timp4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS23838
Target:
研究分野:
Timp2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Timp2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-RS26619
Target:
研究分野:
Timp4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Timp4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
製品番号: HY-162902
CAS 番号: 3001361-04-9
Target:
研究分野:
ALK5-IN-82 is a potent and selective inhibitor against activin receptor-like kinase 5 (ALK5) with an IC50 value of 9.1 nM. ALK5-IN-82 inhibits the protein expression of α-smooth muscle actin (α-SMA), collagen I and tissue inhibitor of metalloproteinase 1 (TIMP-1)/matrix metalloproteinase 13 (MMP-13) in transforming growth factor-β-induced human umbilical vein endothelial cells. ALK5-IN-82 is promising for research of cardiac fibrosis .
製品番号: HY-172258
Target:
研究分野:
5-HT2B antagonist-2 (Compound 19c) is a 5HT2B receptor antagonist with an IC50 of 1.09 nM. 5-HT2B antagonist-2 can downregulate the expression of fibrosis-related genes α-SMA, Timp1, Col1a1, and Col3a1, and significantly reduce the deposition of fibrosis, thereby reducing the fibrotic area and inhibiting the fibrotic process in CCl4-induced liver fibrosis mouse models. 5-HT2B antagonist-2 can be used in the study of immune inflammatory-related diseases, particularly in the research of pulmonary fibrosis diseases .
製品番号: HY-P4890A
製品番号: HY-P992307
Target:
研究分野:
製品番号: HY-RS16840
Target:
研究分野:
Timp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Timp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
