CSE1L - chromosome segregation 1 like Gene

Also Known as CAS; CSE1; XPO2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1434

About CSE1L

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,046,312-49,096,949 (from NCBI)

This gene has 3 transcripts (splice variants), 212 orthologues and 4 paralogues. Broad expression in testis (RPKM 57.6), esophagus (RPKM 21.5) and 24 other tissues.

Summary

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in Apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

CSE1L Products (3)

mRNA Protein Name
NM_001256135.2 NP_001243064.1 exportin-2 isoform 2
NM_001316.4 NP_001307.2 exportin-2 isoform 1
NM_001362762.2 NP_001349691.1 exportin-2 isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17719542 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSE1L Protein Structure

IBN_N

IBN_N: Importin-beta N-terminal domain (29 - 101)

Cse1

Cse1: Cse1 (156 - 525)

CAS_CSE1

CAS_CSE1: CAS/CSE protein, C-terminus (527 - 962)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 971 a.a.
Protein Preferred Names Protein Names

exportin-2

  • CSE1 chromosome segregation 1-like

CSE1L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CSE1L P55060 VAMP5 Homo sapiens O95183
Pull Down
30833792
Intra
CSE1L P55060 P2RY6 Homo sapiens Q15077
Pull Down
30833792
Intra
CSE1L P55060 MS4A4A Homo sapiens Q96JQ5
Pull Down
30833792
Intra
CSE1L P55060 TP53 Homo sapiens P04637
Anti Bait CoIP
17719542
Intra
CSE1L P55060 TP53 Homo sapiens P04637
Crosslink
17719542
Intra
CSE1L P55060 UNC93B1 Homo sapiens Q9H1C4
Pull Down
30833792
Intra
CSE1L P55060 TNFSF13B Homo sapiens Q9Y275
Pull Down
30833792
Cross: Cross-species interaction Intra: Intraspecies interaction

CSE1L Antibodies

Cat. No. Product Name Application Reactivity
HY-P82519 Cellular Apoptosis Susceptibility Antibody (YA2264) WB, IHC-P, ICC/IF, FC Human, Mouse

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N14001 Naamidine J 99.41% Unkown
HY-RS03226 CSE1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CSE1L RGD RGD:1307536
Felis catus CSE1L VGNC VGNC:80076
Bos taurus CSE1L VGNC VGNC:27752
Macaca mulatta CSE1L VGNC VGNC:71512
Canis familiaris CSE1L VGNC VGNC:39651
Mus musculus CSE1L MGD MGI:1339951
Others CSE1L NCBI