Dlg5 - discs large MAGUK scaffold protein 5 Gene

Also Known as mKIAA0583; 4933429D20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71228

Summary

Predicted to enable beta-catenin binding activity and cytoskeletal protein binding activity. Involved in positive regulation of dendritic spine development; positive regulation of synapse assembly; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; apical protein localization; and protein localization to adherens junction. Located in adherens junction; ciliary basal body; and postsynaptic density. Is expressed in several structures, including alimentary system; hemolymphoid system gland; lung; nervous system; and reproductive system. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Dlg5 Products (2)

mRNA Protein Name
NM_001163513.1 NP_001156985.1 disks large homolog 5 isoform 1
NM_027726.1 NP_082002.1 disks large homolog 5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17765678 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apical protein localization IMP
IMP: Inferred from mutant phenotype
23466739 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
23466739 MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity IMP
IMP: Inferred from mutant phenotype
23466739 MGI
acts upstream of or within metanephric collecting duct development IMP
IMP: Inferred from mutant phenotype
17765678 MGI
acts upstream of or within midbrain development IMP
IMP: Inferred from mutant phenotype
17765678 MGI
involved in negative regulation of hippo signaling IMP
IMP: Inferred from mutant phenotype
28087714 MGI
acts upstream of or within neuroepithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
17765678 MGI
acts upstream of or within polarized epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
17765678 MGI
involved in positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
25232112 MGI
involved in positive regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
25644602 MGI
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
25232112 MGI
involved in postsynapse organization IDA
IDA: Inferred from direct assay
25232112 MGI
involved in postsynapse organization IMP
IMP: Inferred from mutant phenotype
25232112 MGI
acts upstream of or within protein localization to adherens junction IMP
IMP: Inferred from mutant phenotype
17765678 MGI
acts upstream of or within protein-containing complex assembly IMP
IMP: Inferred from mutant phenotype
17765678 MGI
acts upstream of or within zonula adherens assembly IMP
IMP: Inferred from mutant phenotype
17765678 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
12657639 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
25644602 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25232112 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
25232112 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25232112 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
25232112 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
25232112 MGI
is active in postsynaptic density IEP
IEP: Inferred from expression pattern
25232112 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

disks large homolog 5

  • discs, large homolog 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03800 DLG5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dlg5 NCBI NCBI:9231