4 Results for "

NFATC3

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "NFATC3" in MCE Product Catalog:

2
Rhamnocitrin
Rhamnocitrin
0 Images
2 Cited Publications
Cat. No.: HY-N1353
CAS No.: 569-92-6
Category:  

Cardiovascular Disease Flavonols other families Flavonoids Phenols Polyphenols Plants Disease Research Fields

Target:  

p38 MAPK

Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) [3] .
NFATC3 Human Pre-designed siRNA Set A
NFATC3 Human Pre-designed siRNA Set A
Cat. No.: HY-RS09241
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

NFATC3 Human Pre-designed siRNA Set A contains three designed siRNAs for NFATC3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CNI103
CNI103
0 Images
Cat. No.: HY-P10889
CAS No.: 2366279-86-7
Target:  

Phosphatase

Research Areas:  

Inflammation/Immunology

CNI103 is a highly potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. CNI103 selectively blocks the interaction between calcineurin and NFATc3 (KD=16 nM), thereby preventing NFATc3 activation in vitro and in vivo. CNI103 can be used to study acute respiratory distress syndrome (ARDS) and other inflammatory diseases .
Rhamnocitrin (Standard)
Rhamnocitrin (Standard)
0 Images
Cat. No.: HY-N1353R
CAS No.: 569-92-6
Category:  

Flavonols other families Flavonoids Phenols Polyphenols Plants

Target:  

Reference Standards Others p38 MAPK

Rhamnocitrin (Standard) is the analytical standard of Rhamnocitrin. This product is intended for research and analytical applications. Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) [3] .
Assay Types