2366279-86-7
Chemical Structure
CNI103
- CAS No.: 2366279-86-7
- Formula:C116H180Cl2N36O26
- Molecular Weight:2565.80
SMILES: O=C(N[C@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)(O)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CNC=N1)C(N[C@@H](C(N[C@H](C(NCCOCCOCC(N[C@@H](CCCCNC(CC[C@H](NC([C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC2=CC=C3C(C=CC=C3)=C2)N4)=O)=O)=O)=O)CCCNC(N)=N)=O)C(N[C@H](CC5=CC=CC=C5)C4=O)=O)=O)C(N)=O)=O)=O)CO)=O)CC(C)C)=O)=O)CCC(N)=O)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)=O)=O)C(C)(C)C)C6=CC=NC(Cl)=C6Cl
Biological Activity: CNI103 is a highly potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. CNI103 selectively blocks the interaction between calcineurin and NFATc3 (KD=16 nM), thereby preventing NFATc3 activation in vitro and in vivo. CNI103 can be used to study acute respiratory distress syndrome (ARDS) and other inflammatory diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CNI103 | 99.56% | CNI103 is a highly potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. CNI103 selectively blocks the interaction between calcineurin and NFATc3 (KD=16 nM), thereby preventing NFATc3 activation in vitro and in vivo. CNI103 can be used to study acute respiratory distress syndrome (ARDS) and other inflammatory diseases. | ||||||||||||||||||||
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