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Cat. No.: HY-N12641

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Ardisianone

Ardisianone is a component with an alkyl benzoquinone structure that can be isolated from Ardisia virens Kurz and Ardisia compressa tea extract. Ardisianone exhibits potent antileukemic activity, particularly against HL-60 cells, with IC₅₀ values of 1.87 μM (24 h) and 1.67 μM (48 h). Ardisianone induces caspase-dependent apoptosis and triggers pyroptosis. Ardisianone can be used for the study of acute myeloid leukemia (AML).

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CAS No.: 66398-68-3
화학식: C₂₄H₃₈O₅
분자량:406.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Ardisianone Chemical Structure

CAS No.: 66398-68-3

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

Ardisianone (1-5 μM, 24-48 h) induces apoptosis and shows potent cytotoxic activity against HL-60 cells, with IC₅₀ values of 1.87 μM (24 h) and 1.67 μM (48 h)^[1].
Ardisianone (2-5 μM, 24 h) exerts pyroptosis-inducing activity in HL-60 cells^[1].
Ardisianone (0.5-2 μM, 72 h) significantly increases CD11b expression and CD68 expression, and induces differentiation into monocyte-like and macrophage-like morphologies in HL-60 cells^[1].
Ardisianone (2 μM) shows DNA damage-inducing activity in HL-60 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HL-60 cells
Concentration:

1, 2, 3, 4, 5 μM
Incubation Time:

3, 6, 9, 12, 15, 24 h
Result:

Induced apoptosis in HL-60 cells and concentration-dependent elevation of sub-G1 apoptotic population.
Induced profound degradation of DFF45/ICAD.
Upregulated death receptors (especially TNFR2).
Downregulated IAPs (cIAP1, cIAP2, survivin).
Promoted time-dependent activation of caspase-8/-3 and degradation of Bid.

Chemical Information

CAS No. 66398-68-3
분자량 406.56
화학식 C₂₄H₃₈O₅
SMILES

CCCCCCCCCCCCC[C@@H](OC(C)=O)CC(C(C(OC)=C1)=O)=CC1=O
Structure Classification
- Quinones
- Benzene Quinones
Initial Source
- Plants
- Primulaceae
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Leu WJ, et al. Antileukemic Natural Product Induced Both Apoptotic and Pyroptotic Programmed Cell Death and Differentiation Effect. Int J Mol Sci. 2021 Oct 18;22(20):11239. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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