89-00-9
89-00-9
Chemical Structure
Quinolinic acid
- CAS No.: 89-00-9
- Formula:C7H5NO4
- Molecular Weight:167.12
IUPAC Name: pyridine-2,3-dicarboxylic acid
InChIKey: GJAWHXHKYYXBSV-UHFFFAOYSA-N
SMILES: O=C(C1=NC=CC=C1C(O)=O)O
Biological Activity: Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis[1][2][3][4][5][6][7][8].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Quinolinic acid | 99.97% | Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis. | ||||||||||||||||||||
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Quinolinic acid (Standard) | 99.96% | Quinolinic acid (Standard) is the analytical standard of Quinolinic acid. This product is intended for research and analytical applications. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis. | ||||||||||||||||||||
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Quinolinic acid-13C3,15N | 99.76% | Quinolinic acid-13C3, 15N (2,3-Pyridinedicarboxylic Acid-13C3, 15N) is the 13C- and 15N-labeled Quinolinic acid (HY-100807). Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction. | ||||||||||||||||||||
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Quinolinic acid-13C7 | Quinolinic acid-13C7 is the 13C labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis. | |||||||||||||||||||||
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Quinolinic acid-13C4,15N | 98.80% | Quinolinic acid-13C4, 15N is an isotopic labeled Quinolinic acid (HY-100807). Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis. | ||||||||||||||||||||
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Quinolinic acid-d3 | 99.90% | Quinolinic acid-d3 is the deuterium labeled Quinolinic acid. Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis. | ||||||||||||||||||||
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References
- [1]. Heyes MP, et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain. 1992 Oct;115 ( Pt 5):1249-73. [Content Brief]
- [2]. Jang S, et al. Neuroprotective effects of (-)-epigallocatechin-3-gallate against quinolinic acid-induced excitotoxicity via PI3K pathway and NO inhibition. Brain Res. 2010 Feb 8;1313:25-33. [Content Brief]
- [3]. Sugisawa E, et al. Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia. Cell Rep. 2022 Mar 8;38(10):110462. [Content Brief]
- [4]. Lisak RP, et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp Neurol. 2015 Nov;273:161-7. [Content Brief]
- [5]. Lapin IP. Stimulant and convulsive effects of kynurenines injected into brain ventricles in mice. J Neural Transm. 1978;42(1):37-43. [Content Brief]
- [6]. Bains M, et al. Anti-inflammatory effects of ellagic acid and vanillic acid against quinolinic acid-induced rat model of Huntington's disease by targeting IKK-NF-κB pathway. Eur J Pharmacol. 2022 Nov 5;934:175316. [Content Brief]
- [7]. Goel F, et al. Protective effects of diacerein against quinolinic acid-induced Huntington's disease-like symptoms in adult zebrafish by targeting GSK-3β signalling. Naunyn Schmiedebergs Arch Pharmacol. 2025 Aug;398(8):10799-10821. [Content Brief]
- [8]. Martínez-Gopar PE, et al. Mast cells and histamine are involved in the neuronal damage observed in a quinolinic acid-induced model of Huntington's disease. J Neurochem. 2022 Jan;160(2):256-270. [Content Brief]
