Huntington's Disease (HD) Models
Quinolinic acid
- Formula: C7H5NO4
- Molecular Weight: 167.12
Quinolinic acid, an endogenous metabolite of tryptophan, is a N-methyl-D-aspartate receptor (NMDA receptor) agonist. Quinolinic acid increases glutamate efflux, induces the generation of ROS, activates nitric oxide synthase, produces excessive NO, leading to calcium ion influx and neuronal apoptosis.
3-Nitropropanoic acid
Synonyms: β-Nitropropionic acid; Bovinocidin
- Formula: C3H5NO4
- Molecular Weight: 119.08
3-Nitropropanoic acid (β-Nitropropionic acid) is an irreversible and orally active inhibitor of succinate dehydrogenase. 3-Nitropropanoic acid exhibits potent antimycobacterial activity with a MIC value of 3.3 μM. 3-Nitropropanoic acid can induce cell apoptosis.
