TGFA - transforming growth factor alpha Gene
Also Known as TFGA
Species: Homo sapiens
About TGFA
This gene has 9 transcripts (splice variants), 187 orthologues, 5 paralogues and is associated with 2 phenotypes. Broad expression in esophagus (RPKM 11.6), gall bladder (RPKM 8.1) and 17 other tissues.
Summary
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
TGFA Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001099691.3 | NP_001093161.1 | protransforming growth factor alpha isoform 2 preproprotein |
| NM_001308158.2 | NP_001295087.1 | protransforming growth factor alpha isoform 3 precursor |
| NM_001308159.2 | NP_001295088.1 | protransforming growth factor alpha isoform 4 precursor |
| NM_003236.4 | NP_003227.1 | protransforming growth factor alpha isoform 1 preproprotein |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables epidermal growth factor receptor binding |
IDA
IDA: Inferred from direct assay
|
6315706 | GOA |
| enables growth factor activity |
IDA
IDA: Inferred from direct assay
|
11278323 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12297049 | GOA |
| enables receptor ligand activity |
IDA
IDA: Inferred from direct assay
|
8702723 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in ERBB2-EGFR signaling pathway |
IDA
IDA: Inferred from direct assay
|
8702723 | GOA |
| involved in cell surface receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
11278323 | GOA |
| acts upstream of or within epidermal growth factor receptor signaling pathway |
IDA
IDA: Inferred from direct assay
|
6315706 | GOA |
| acts upstream of positive regulation of MAPK cascade |
IDA
IDA: Inferred from direct assay
|
11278323 | GOA |
| involved in positive regulation of epithelial cell proliferation |
IDA
IDA: Inferred from direct assay
|
11278323 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in basolateral plasma membrane |
IDA
IDA: Inferred from direct assay
|
17553928 | GOA |
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
12743035 | GOA |
| located in cytoplasmic vesicle |
IDA
IDA: Inferred from direct assay
|
15064403 | GOA |
| is active in extracellular space |
IDA
IDA: Inferred from direct assay
|
8702723 | GOA |
| located in extracellular space |
IDA
IDA: Inferred from direct assay
|
12743035 | GOA |
| located in perinuclear region of cytoplasm |
IDA
IDA: Inferred from direct assay
|
15064403 | GOA |
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protransforming growth factor alpha |
|
TGFA Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
TGFA | P01135 | NKD2 | Homo sapiens | Q969F2 | 18757723 | |
|
Intra
|
TGFA | P01135 | EGFR | Homo sapiens | P00533 | 12297049 | |
|
Intra
|
TGFA | P01135 | SGTA | Homo sapiens | O43765 | 25416956 | |
|
Intra
|
TGFA | P01135 | SGTA | Homo sapiens | O43765 | 25416956 | |
|
Cross
|
TGFA | P01135 | Magi3 | Mus musculus | Q9EQJ9 | 15652357 | |
|
Cross
|
TGFA | P01135 | Magi3 | Mus musculus | Q9EQJ9 | 15652357 | |
|
Cross
|
TGFA | P01135 | Magi3 | Mus musculus | Q9EQJ9 | 15652357 |
Recombinant TGFA Proteins
| Cat. No. | 상품명 | Accession | Purity |
|---|---|---|---|
| HY-P7296 | TGF alpha/TGFA Protein, Human (CHO) | P01135 (V40-A89) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7411 | TGF alpha/TGFA Protein, Human | P01135 (V40-A89) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700149AF | Animal-Free TGF alpha/TGFA Protein, Human (His) | P01135 (V40-A89) | ≥ 95%, as determined by reducing SDS-PAGE. |
TGFA Antibodies
| Cat. No. | 상품명 | 신청 | Reactivity |
|---|---|---|---|
| HY-P80911 | TGF alpha Antibody (YA037) | WB, IHC-P, IP | Human |
| HY-P80911A | TGF alpha Antibody (YA037)(PBS only) | WB, IHC-P, IP | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Tooth Agenesis |
|
|
| Cleft Lip |
|
|
| Cholesteatoma Of Middle Ear |
|
|
| Gastritis, Familial Giant Hypertrophic |
|
|
| Cleft Lip With Or Without Cleft Palate |
|
|
| Oral Leukoplakia |
|
|
| Cleft Lip/Palate |
|
|
| Endometrial Cancer |
|
|
| Adenocarcinoma |
|
|
| Secondary Hyperparathyroidism |
|
|
| Cleft Palate, Isolated |
|
|
| Papilloma |
|
|
| Breast Cancer |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Alzheimer Disease 6 |
|
|
| Gastritis |
|
|
| Atrophic Gastritis |
|
|
| Pancreatic Cancer |
|
|
| Squamous Cell Carcinoma |
|
|
| Lung Cancer |
|
|
| Colorectal Cancer |
|
|
| Breast Disease |
|
|
| Pancreatic Adenocarcinoma |
|
|
| Acanthosis Nigricans |
|
|
| Glioma |
|
|
| Esophageal Cancer |
|
|
| Psoriasis |
|
|
| Gastric Cancer |
|
|
| Colon Adenocarcinoma |
|
|
| Mucositis |
|
|
| Ovarian Cancer |
|
|
| Prostate Cancer |
|
|
| Hepatocellular Adenoma |
|
|
| Bladder Cancer |
|
|
| Retinal Hemangioblastoma |
|
|
| Hypereosinophilic Syndrome, Idiopathic |
|
|
| Hepatocellular Carcinoma |
|
|
| Pheochromocytoma |
|
|
| Skin Disease |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Gastroesophageal Reflux |
|
|
| Van Der Woude Syndrome |
|
|
| Meningioma, Familial |
|
|
| Orofacial Cleft |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Myelodysplastic Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | TGFA | MGD | MGI:98724 |
| Macaca mulatta | TGFA | VGNC | VGNC:78331 |
| Felis catus | TGFA | VGNC | VGNC:66130 |
| Rattus norvegicus | TGFA | RGD | RGD:3849 |
| Bos taurus | TGFA | VGNC | VGNC:58421 |
| Others | TGFA | NCBI |