NODAGA-LM3
Based on 1 Customer Validation
NODAGA-LM3 is a ligand that can cross the blood-brain barrier and targets somatostatin receptor SSTR2 with high affinity (IC50 = 1.3 nM). NODAGA-LM3 does not trigger the internalization of SSTR2 and can inhibit agonist-induced internalization processes. NODAGA-LM3 shows low uptake in normal tissues such as the liver and spleen, but high uptake in the lungs and blood pool. 68Ga-labeled NODAGA-LM3 can serve as a PET imaging agent for well-differentiated neuroendocrine tumors, and is applied in studies related to small cell lung cancer and well-differentiated neuroendocrine tumors.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.65%
- 화학식: C68H90ClN15O19S2
- 분자량:1521.11
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Radionuclide-Drug Conjugates (RDCs) Isoforms
More
Biological Activity
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SSTR2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Appearance Solid
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분자량 1521.11
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화학식 C68H90ClN15O19S2
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Color White to off-white
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Sequence
{NODAGA}-{p-Cl-Phe}-{d-Cys}-Tyr-{d-Phe(4-amino-carbamoyl)}-Lys-Thr-Cys-{d-Tyr}-NH2 (Disulfide bridge: Cys2-Cys7)
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Sequence Shortening
{NODAGA}-{p-Cl-Phe}-{d-Cys}-Y-{d-Phe(4-amino-carbamoyl)}-KTC-{d-Tyr}-NH2 (Disulfide bridge: Cys2-Cys7)
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMSO : 66.67 mg/mL (43.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (283 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6574 mL | 3.2871 mL | 6.5741 mL | 16.4354 mL |
| 5 mM | 0.1315 mL | 0.6574 mL | 1.3148 mL | 3.2871 mL | |
| 10 mM | 0.0657 mL | 0.3287 mL | 0.6574 mL | 1.6435 mL | |
| 15 mM | 0.0438 mL | 0.2191 mL | 0.4383 mL | 1.0957 mL | |
| 20 mM | 0.0329 mL | 0.1644 mL | 0.3287 mL | 0.8218 mL | |
| 25 mM | 0.0263 mL | 0.1315 mL | 0.2630 mL | 0.6574 mL | |
| 30 mM | 0.0219 mL | 0.1096 mL | 0.2191 mL | 0.5478 mL | |
| 40 mM | 0.0164 mL | 0.0822 mL | 0.1644 mL | 0.4109 mL |
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