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Cat. No.: HY-149389

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PNMT-IN-1

PNMT-IN-1 (inhibtor 4) is a specific inhibitor of phenylethanolamine N-methyltransferas (PNMT) with a K_i value of 1.2 nM and a IC₅₀ value of 81 nM. PNMT-IN-1 also inhibits the vitality of DNMT1 and DNMT3b, with the IC₅₀ value of 61 μM and 17 μM, respectively, and has an antagonistic effect on epinephrine.PNMT-IN-1 (inhibtor 4 ) is a second generation inhibitor.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₇H₃₆Cl₂N₈O₅
분자량:623.53

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

PNMT-IN-1 Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC50:81 nM (Phenylethanolamine N-methyltransferase, PNMT )^[1] IC50:61 nM (DNMT1)^[1] IC50:17 nM (DNMT3b)^[1]

All Adrenergic Receptor Isoforms :

In Vitro

PNMT-IN-1(inhibtor 4)(0.01 μM, 4h) inhibts the activity of hPNMT (IC₅₀= 81 nM) but don’t affect protein methylation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:

Overexpressed hPNMT in HEK293T cells using a lentiviral vector^[1]
Concentration:

0-10 μM
Incubation Time:

24 h
Result:

Inhibted the activity of hPNMT (IC₅₀=81nM)

Western Blot Analysis

Cell Line:

HT-29 cell^[1]
Concentration:

10 μg
Incubation Time:

6 days
Result:

Changed total SDMA, ADMA, and Me3-lysine not significant.

Chemical Information

분자량 623.53
화학식 C₂₇H₃₆Cl₂N₈O₅
SMILES

ClC1=C(Cl)C=CC2=C1CNCC2CCCCN(C[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C=NC5=C4N=CN=C5N)O3)CC[C@H](N)C(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Niusha Mahmoodi, et al. Cell-Effective Transition-State Analogue of Phenylethanolamine N‑Methyltransferase. Biochemistry. 2023, 62(15), 2257-2268. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

PNMT-IN-1

All Adrenergic Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PNMT-IN-1 Related Classifications

HY-149389 Related Classifications