SENP1-IN-4
Based on 1 Customer Validation
SENP1-IN-4 is a specific deSUMOylation protease 1 (SENP1) inhibitor extracted from patent CN110627860, Compound 21. SENP1-IN-4 is developed for tumor radiosensitivity enhancement.
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- Purity: 98.0%
- CAS No.: 2416910-64-8
- 화학식: C33H54N2O3
- 분자량:526.79
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보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
>20 μM
Compound: 36
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Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
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[PMID: 34688014] |
SENP1-IN-4 improves the sensitivity of tumor cells to irradiation[1].
SENP1-IN-4 (0.7-20 μM; 72 hours) has cytotoxic for Hella cells with an IC50 of >20 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hela cells
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Concentration:0.7 μ M, 2.2 μM, 6.6 μM、20 μM
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Incubation Time:72 hours
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Result:IC50>20 μM
Chemical Information
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CAS No. 2416910-64-8
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Appearance Solid
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분자량 526.79
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화학식 C33H54N2O3
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Color White to off-white
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SMILES
CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])[C@@H](C)[C@H](C)CC[C@@](C(NCC(NC)=O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 100 mg/mL (189.83 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8983 mL | 9.4914 mL | 18.9829 mL | 47.4572 mL |
| 5 mM | 0.3797 mL | 1.8983 mL | 3.7966 mL | 9.4914 mL | |
| 10 mM | 0.1898 mL | 0.9491 mL | 1.8983 mL | 4.7457 mL | |
| 15 mM | 0.1266 mL | 0.6328 mL | 1.2655 mL | 3.1638 mL | |
| 20 mM | 0.0949 mL | 0.4746 mL | 0.9491 mL | 2.3729 mL | |
| 25 mM | 0.0759 mL | 0.3797 mL | 0.7593 mL | 1.8983 mL | |
| 30 mM | 0.0633 mL | 0.3164 mL | 0.6328 mL | 1.5819 mL | |
| 40 mM | 0.0475 mL | 0.2373 mL | 0.4746 mL | 1.1864 mL | |
| 50 mM | 0.0380 mL | 0.1898 mL | 0.3797 mL | 0.9491 mL | |
| 60 mM | 0.0316 mL | 0.1582 mL | 0.3164 mL | 0.7910 mL | |
| 80 mM | 0.0237 mL | 0.1186 mL | 0.2373 mL | 0.5932 mL | |
| 100 mM | 0.0190 mL | 0.0949 mL | 0.1898 mL | 0.4746 mL |
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