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Cat. No.: HY-177493A

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SSTR3 agonist-1 TFA

SSTR3 agonist-1 TFA is a potent, orally active, and selective SSTR3 agnoist (EC₅₀ =0.14 nM). SSTR3 agonist-1 TFA binds to SSTR3 receptor to inhibit cAMP activity. SSTR3 agonist-1 TFA decreases kidney weight and kidney cystic index (KCI) in a mouse model of autosomal dominant polycystic kidney disease (ADPKD). SSTR3 agonist-1 TFA can be used for ADPKD research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₃₃H₃₈F₇N₅O₆
분자량:733.67

보관:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Data Sheet (275 KB)

SSTR3 agonist-1 TFA Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

SSTR3

0.14 nM (EC₅₀)

All Somatostatin Receptor Isoforms :

In Vitro

SSTR3 agonist-1 (compound 38) (20 min) TFA inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in CHO-K1 cells stably expressing human SSTR3, with an EC₅₀ of 0.14 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SSTR3 agonist-1 (compound 38) (30 and 60 mg/kg, p.o., daily for 9 days from potsnatal days (PND) 12 to 20) TFA dose dependently decreases KCI and kidney size in the ADPKD mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Pax8 Tet-O-Cre/Pkd1 flox mice treated with Doxycycline (HY-N0565) hyclate (50 mg/kg) to induce ADPKD^[1]
Dosage:

30 and 60 mg/kg
Administration:

p.o., daily for 9 days from (PND) 12 to 20
Result:

Decreased KCI with a 10.7% suppression compared to the vehicle at 30 mg/kg.
Decreased KCI with a 25.2% suppression compared to the vehicle at 60 mg/kg.
Dose dependently decreased the left kidney weight/body weight (LKW/BW) ratio.

Chemical Information

Appearance Solid
분자량 733.67
화학식 C₃₃H₃₈F₇N₅O₆
Color Yellow to brown
SMILES

O=C(C1=C(N=C2C=C(C(OC)=CC2=C1N3CC[C@H](C)NCC3)C(F)(F)F)N4CCOCC4)N[C@@H](C)C5=CC(OC)=C(F)C=C5.O=C(O)C(F)(F)F
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim S. H., et al. Somatostatin Subtype Receptor 3 (SSTR3) Agonists and Uses Thereof. WO2025111318A1. 2025-05-30.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

SSTR3 agonist-1 TFA

All Somatostatin Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

SSTR3 agonist-1 TFA Related Classifications

HY-177493A Related Classifications