country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-153501

Copy Link Print Information

TrkA-IN-5

TrkA-IN-5 is a TrkA inhibitor with an IC₅₀ value of 1.678 nM against TrkA. TrkA-IN-5 can be used in cancer research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1377503-70-2
화학식: C₂₅H₁₈F₃N₅O₂S
분자량:509.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

TrkA-IN-5 Chemical Structure

CAS No.: 1377503-70-2

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

TrkA-IN-5 is a TrkA inhibitor with an IC₅₀ value of 1.678 nM against TrkA. TrkA-IN-5 can be used in cancer research^[1].

IC₅₀ & Target^[1]

TrkA

1.678 nM (IC₅₀)

All Trk Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	GI	40 % Compound: 6t	Cytotoxicity against human MCF7 cells assessed as growth inhibition at 0.1 to 50 uM after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as growth inhibition at 0.1 to 50 uM after 48 hrs by MTT assay	[PMID: 22575050]
MCF7	IC₅₀	4.2 μM Compound: 6t	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 22575050]

In Vitro

TrkA-IN-5 (Compound 20) potently inhibits human TrkA (PDB ID: 4aoj) with an IC₅₀ value of 1.678 nM. It forms multiple stable hydrogen bonds and hydrophobic interactions with the active site of this protein, and its activity can be accurately predicted by CoMFA and CoMSIA 3D-QSAR models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1377503-70-2
분자량 509.51
화학식 C₂₅H₁₈F₃N₅O₂S
SMILES

O=S(=O)(NC1=CC(N)=CC(=C1)C2=CN=C3NC=C(C=4C=CN=CC4)C3=C2)C=5C=CC=C(C5)C(F)(F)F
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Adnane Aouidate, et al. Molecular Docking and 3D-QSAR Studies on 7-azaindole Derivatives as
Inhibitors of Trk A: A Strategic Design in Novel Anticancer Agents. Letters in Drug Design & Discovery, 2018, 15, 1211-1223.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

TrkA-IN-5

All Trk Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

TrkA-IN-5 Related Classifications

HY-153501 Related Classifications