Neptinib
Neptinib (NEP010) is an orally active derivative of Afatinib (HY-10261) that has stronger antitumor activity than Afatinib (HY-10261) by improving pharmacokinetics. Neptinib has a significant inhibitory effect on tumor growth in mouse non-small cell lung cancer models with different EGFR mutations. Neptinib has a certain inhibitory effect on the EGFR kinase family, with IC50 values ??of 0.24 nM, 7.25 nM, 0.46 nM and 1.79 nM for EGFRwt, EGFRL858R/T790M, EGFRL858R and EGFRT790M, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2085843-51-0
- Formula: C22H23ClFN5O2
- Molecular Weight:443.90
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All EGFR Isoforms
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Biological Activity
|
EGFR (WT) 0.24 nM (IC50) |
EGFRL858R/T790M 7.25 nM (IC50) |
EGFRL858R 0.46 nM (IC50) |
EGFRT790M 1.79 nM (IC50) |
Chemical Information
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CAS No. 2085843-51-0
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Molecular Weight 443.90
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Formula C22H23ClFN5O2
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SMILES
FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=C2C=C(NC(/C=C/CN(C)C)=O)C(OCC)=C3
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Synonyms
NEP010
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neptinib Related Classifications
HY-164503 Related Classifications
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