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E4F1 - E4F transcription factor 1 Gene

Also Known as E4F

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1877

About E4F1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,223,591-2,235,742 (from NCBI)

This gene has 9 transcripts (splice variants), 191 orthologues and 38 paralogues. Ubiquitous expression in spleen (RPKM 6.6), prostate (RPKM 5.8) and 25 other tissues.

Summary

The Zinc Finger Protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]

E4F1 Products (3)

mRNA	Protein	Name
NM_001288776.2	NP_001275705.2	transcription factor E4F1 isoform 2
NM_001288778.2	NP_001275707.2	transcription factor E4F1 isoform 3
NM_004424.5	NP_004415.4	transcription factor E4F1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9121437	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16652157	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	2169022	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	14645522	GOA
enables cAMP response element binding	IDA IDA: Inferred from direct assay	14645522	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10869426	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14645522	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9121437	GOA
involved in regulation of cell cycle process	IDA IDA: Inferred from direct assay	14645522	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

E4F1 Protein Structure

zf-C2H2_6

zf-C2H2

zf-H2C2_2

0
200
400
600
784 a.a.

Protein Preferred Names	Protein Names
transcription factor E4F1	RING-type E3 ubiquitin transferase E4F1

E4F1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	E4F1	Q66K89	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	12730668
Intra	E4F1	Q66K89	ANP32A	Homo sapiens	P39687	Anti Tag CoIP	17557114
Intra	E4F1	Q66K89	ANP32A	Homo sapiens	P39687	Pull Down	17557114
Intra	E4F1	Q66K89	RASSF1	Homo sapiens	Q9NS23-2	Anti Tag CoIP	14729613
Intra	E4F1	Q66K89	RASSF1	Homo sapiens	Q9NS23-2	Anti Bait CoIP	14729613
Cross	E4F1	Q66K89	lnx2b	Danio rerio	A4VCF7	Pull Down	21666599
Cross	E4F1	Q66K89	tcf7l1a	Danio rerio	Q9YHE8	Anti Tag CoIP	21666599
Cross	E4F1	Q66K89	gam1_adeg1	Fowl adenovirus A	Q64770	Pull Down	12730668
Cross	E4F1	Q66K89	gam1_adeg1	Fowl adenovirus A	Q64770	CoIP	12730668
Cross	E4F1	Q66K89	gam1_adeg1	Fowl adenovirus A	Q64770	Anti Tag CoIP	12730668

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations	Severe Congenital Encephalopathy Due To Mecp2 Mutation Severe Neonatal-Onset Encephalopathy With Microcephaly Encephalopathy, Neonatal Severe Neonatal Severe Encephalopathy Due To Mecp2 Mutations Mecp2-Related Severe Neonatal Encephalopathy Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy Severe Neonatal Encephalopathy Due To Mecp2 Mutations ENS-MECP2 Encephalopathy, Neonatal, Severe
Renal Artery Obstruction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04118	E4F1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	E4F1	RGD	RGD:1596731
Bos taurus	E4F1	VGNC	VGNC:28293
Macaca mulatta	E4F1	VGNC	VGNC:72028
Felis catus	E4F1	VGNC	VGNC:80566
Mus musculus	E4F1	MGD	MGI:109530
Others	E4F1	NCBI