1 Result for "

2492429-45-3

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "2492429-45-3" in MCE Product Catalog:

Cat. No.: HY-147825
CAS No.: 2492429-45-3
Target:  

EGFR Raf Apoptosis

Research Areas:  

Cancer

EGFR/BRAFV600E-IN-1 (Compound 23) is a potent EGFR and BRAF V600E dual inhibitor with IC50s of 0.08 and 0.15 µM, respectively. EGFR/BRAFV600E-IN-1 induces apoptosis and cell cycle arrest in both pre-G1 and G2/M phases. EGFR/BRAFV600E-IN-1 exhibits antiproliferative activity againist A-549, MCF-7, Panc-1, HT-29 with IC50s of 1.2, 0.79, 1.3, and 1.23 µM, respectively .
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