1 Result for "

Avapritinib-d3

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Avapritinib-d3" in MCE Product Catalog:

Cat. No.: HY-W754911
CAS No.: 2408934-57-4
Synonyms: BLU-285-d3
Avapritinib-d3 (BLU-285-d3) is deuterium labeled Avapritinib. Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2 .
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