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BAY 1101042

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Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-109136
    Runcaciguat
    1 Publications Verification

    BAY 1101042

    		 Guanylate Cyclase Cardiovascular Disease Metabolic Disease
    Runcaciguat (BAY 1101042) is a selective, orally active, allosteric activator of soluble guanylate cyclase (sGC) that specifically targets its oxidized and heme-free form. Runcaciguat binds to sGC in a histidine-dependent manner and restores cyclic guanosine monophosphate (cGMP) production under oxidative stress, independent of nitric oxide (NO) or heme. Runcaciguat exhibits renoprotective and cardioprotective activities, such as reduced proteinuria and improved renal function. Runcaciguat is primarily being studied in chronic kidney disease (CKD) associated with hypertension, diabetes, and metabolic disorders, as well as potential cardiovascular indications such as heart failure with preserved ejection fraction (HFpEF) .
    Runcaciguat

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