3 Results for "

BOLD

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "BOLD" in MCE Product Catalog:

6
2-PMPA sodium
2-PMPA sodium
0 Images
6 Publications Verification
Cat. No.: HY-100788C
CAS No.: 373645-42-2
Synonyms: 2-(Phosphonomethyl)pentanedioic acid sodium
Target:  

Carboxypeptidase

연구분야:  

Neurological Disease

2-PMPA (2-(Phosphonomethyl)pentanedioic acid) sodium is a glutamate carboxypeptidase II (GCPII) inhibitor with an IC50 of 0.0003 μM. 2-PMPA sodium shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG, regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA sodium is applicable to the research of neurological diseases .
1
BOLD-100
BOLD-100
0 Images
1 Cited Publications
Cat. No.: HY-16350
CAS No.: 197723-00-5
Synonyms: NKP-1339; IT-139; KP-1339
Target:  

DNA/RNA Synthesis Apoptosis

연구분야:  

Cancer

BOLD-100 (NKP-1339; IT-139) is the first-in-class ruthenium-based anticancer agent in development against solid cancer with limited side effects. BOLD-100 induces G2/M cell cycle arrest, blockage of DNA synthesis, and induction of apoptosis via the mitochondrial pathway. BOLD-100 has a high tumor targeting potential, strongly binds to serum proteins such as albumin and transferrin and activates in the reductive tumor milieu .
BOLD-100 free base
BOLD-100 free base
0 Images
Cat. No.: HY-147039
CAS No.: 783324-98-1
Synonyms: NKP-1339 free base; IT-139 free base; KP-1339 free base
Target:  

HSP Autophagy

연구분야:  

Cancer

BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution .
Assay Types