783324-98-1
Chemical Structure
BOLD-100 free base
Synonym(s): NKP-1339 free base; IT-139 free base; KP-1339 free base
- CAS No.: 783324-98-1
- Formula:C14H12Cl4N4Ru
- Molecular Weight:479.15
IUPAC Name: 2-amino-8-oxononanoic acid hydrochloride
InChIKey: SIHKLNQDIVPAOH-UHFFFAOYSA-J
SMILES: [Cl-][Ru+4]([Cl-])([Cl-])([N]1=CC2=CC=CC=C2N1)([N]3=CC4=CC=CC=C4N3)[Cl-]
Biological Activity: BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
BOLD-100 free base | BOLD-100 (NKP-1339; IT-139) free base is a ruthenium-based anticancer agent. BOLD-100 free base also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 free base interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
