1 Result for "

DQ-9

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "DQ-9" in MCE Product Catalog:

Cat. No.: HY-183683
CAS No.: 2803611-81-4
Target:  

Proteasome Apoptosis

Research Areas:  

Cancer

DQ-9 is a selective immunoproteasome β5i inhibitor (IC50=0.0019 μM). DQ-9 generates additional inhibitory substances via iron-mediated intracellular activation, and induces oxidative stress, carbon-centered free radicals and macromolecular damage through its artemisinin domain. DQ-9 induces apoptosis in leukemia and multiple myeloma cells. DQ-9 exhibits selective cytotoxicity against leukemia and multiple myeloma cells by elevating the labile iron pool. DQ-9 can be used in the research of hematological malignancies (leukemia, multiple myeloma, mantle cell lymphoma, acute myeloid leukemia) .
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