1 Result for "

EM3 cells

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "EM3 cells" in MCE Product Catalog:

Cat. No.: HY-P991641
Synonyms: LY3012218

Target:  

FLT3 p38 MAPK STAT PI3K Akt

Research Areas:  

Cancer

IMC-EB10 (LY3012218) is an anti-FLT3 monoclonal antibody. IMC-EB10 binds to FLT3 with high affinity (Kd = 158 pM) and blocks the binding of FLT3 ligand to FLT3 (IC50 ≈ 10 nM), thereby inhibiting MAPK, STAT5, and PI3K/Akt signaling in leukemia cells. IMC-EB10 can enhance the anti-leukemic effect of Methotrexate (HY-14519) and inhibit leukemias expressing wild-type or ITD-mutated FLT3 receptors. IMC-EB10 prolongs the survival of acute lymphoblastic leukemia (ALL) cells and primary leukemia samples and reduces engraftment in non-obese diabetic/severe combined immunodeficiency patients. IMC-EB10 is indicated for leukemia research .
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